The concept of dose is important in clinical medicine. In the pharmacological treatment of many conditions, physicians typically start with a dose of a drug believed to be the minimum effective dose. If the patient does not respond, this initial dose may then be titrated upward to a maximum dose, beyond which the adverse effects of the drug are unacceptable for treatment. Thus, all marketed drugs require data on their efficacy and safety.
Physical activity, while not a drug, can behave like one—it causes many physiological changes in the body (often beneficial for health),1 helps prevent the development of many chronic diseases,2 and is a useful adjunct to drug treatment for many diseases, including cardiovascular disease, cancer, and diabetes.3- 4 Health care professionals, including physicians, are encouraged to prescribe physical activity for health.3- 4 It is plausible that there is a minimum dose of physical activity for health benefits, that these benefits increase with increasing dose, and that beyond a certain dose, adverse effects (eg, musculoskeletal injuries,5 sudden death6) outweigh benefits.
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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