Author Contributions: Drs Seddon and Rosner had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Seddon, Rosner, Klein.
Acquisition of data: Seddon, Schultz, Klein.
Analysis and interpretation of data: Seddon, Rosner, Francis, George, Klein.
Drafting of the manuscript: Seddon, George, Rosner.
Critical revision of the manuscript for important intellectual content: Seddon, Francis, George, Schultz, Rosner, Klein.
Statistical analysis: Rosner, Seddon.
Obtained funding: Seddon, Klein.
Administrative, technical, or material support: Seddon, Francis, George, Klein.
Study supervision: Seddon, Rosner, Klein.
Financial Disclosures: Dr Seddon reports that she is named as an inventor on a patent application (US Patent Application No. 11/066,641, filed by Massachusetts Eye and Ear Infirmary on February 25, 2005, and published as US-2005-0250745-A1 on November 10, 2005) regarding biomarkers for age-related macular degeneration.
Funding/Support: This work is supported by grants EY12203 (Dr Klein) and R01-EY11309 (Dr Seddon) from the National Eye Institute; unrestricted grants from the Research to Prevent Blindness Inc, New York, NY (Drs Seddon, Francis, Schultz, and Klein), the Foundation Fighting Blindness, Owing Mills, Md (Drs Seddon and Francis), the Genetics of AMD Research Fund (Dr Seddon), the Macular Degeneration Center Research Fund, Casey Eye Institute, Oregon Health & Science University, Portland (Dr Klein), the Massachusetts Lions Eye Research Fund Inc, Northboro (Dr Seddon); and grant U54 RR020278 from the National Center for Research Resources to the Broad Institute Center for Genotyping and Analysis (Dr Seddon).
Role of the Sponsor: The funding organizations did not influence the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation or approval of the manuscript.
Acknowledgment: We thank the AREDS participants and investigators and the EMMES Corporation for their work on the AREDS Genetic Repository; Mark Daly, PhD, assistant professor of medicine, and David Altshuler, MD, PhD, associate professor of genetics and medicine, Harvard Medical School, for their advice and support; Richard G. Weleber, MD, Casey Eye Institute, Oregon Health and Science University, for his advice and support; Jesen Fagerness, BS, and Julian Maller, BS, Center for Human Genetic Research, Massachusetts General Hospital, and Daniel Mirel, PhD, Broad Institute, Cambridge, Mass, for their assistance with genotyping; and Marion McPhee, BEd, Harvard University Channing Laboratory, Boston, Mass, for her programming assistance; and Sara Hamon, Rockefeller University, New York, NY, for helpful comments. Dr Weleber received grant support and Ms McPhee received consultation fees from grants for work on this study.