Author Contributions: Dr Rossouw had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Rossouw, Prentice, Manson, Barad, Barnabei.
Acquisition of data: Prentice, Manson, Barad, Ko, LaCroix, Stefanick.
Analysis and interpretation of data: Rossouw, Prentice, Manson, Wu, Barad, Barnabei, LaCroix, Margolis.
Drafting of the manuscript: Rossouw, Wu, Ko.
Critical revision of the manuscript for important intellectual content: Prentice, Manson, Wu, Barad, Barnabei, Ko, LaCroix, Margolis, Stefanick.
Statistical analysis: Prentice, Wu, LaCroix.
Obtained funding: Rossouw, Prentice, Manson, Stefanick.
Administrative, technical, or material support: Rossouw, Prentice, Manson.
Study supervision: Rossouw, Margolis.
Financial Disclosures: Dr LaCroix reported serving as a consultant to Procter & Gamble and receiving funding from Pfizer. None of the other authors reported disclosures.
Funding/Support: The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services. The study drugs were supplied by Wyeth Research (St Davids, Pa).
Role of the Sponsors: The National Institutes of Health had input into design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation of the manuscript. Wyeth did not participate in any aspect of the aforementioned.
Program Office: National Heart, Lung, and Blood Institute, Bethesda, Md (Elizabeth Nabel, Jacques Rossouw, Shari Ludlam, Linda Pottern, Joan McGowan, Leslie Ford, and Nancy Geller).
Clinical Coordinating Centers: Fred Hutchinson Cancer Research Center, Seattle, Wash (Ross Prentice, Garnet Anderson, Andrea LaCroix, Charles L. Kooperberg, Ruth E. Patterson, Anne McTiernan); Wake Forest University School of Medicine, Winston-Salem, NC (Sally Shumaker); Medical Research Labs, Highland Heights, Ky (Evan Stein); University of California at San Francisco, San Francisco (Steven Cummings).
Clinical Centers: Albert Einstein College of Medicine, Bronx, NY (Sylvia Wassertheil-Smoller); Baylor College of Medicine, Houston, Tex (Jennifer Hays); Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (JoAnn Manson); Brown University, Providence, RI (Annlouise R. Assaf); Emory University, Atlanta, Ga (Lawrence Phillips); Fred Hutchinson Cancer Research Center, Seattle, Wash (Shirley Beresford); George Washington University Medical Center, Washington, DC (Judith Hsia); Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, Calif (Rowan Chlebowski); Kaiser Permanente Center for Health Research, Portland, Ore (Evelyn Whitlock); Kaiser Permanente Division of Research, Oakland, Calif (Bette Caan); Medical College of Wisconsin, Milwaukee (Jane Morley Kotchen); MedStar Research Institute/Howard University, Washington, DC (Barbara V. Howard); Northwestern University, Chicago/Evanston, Ill (Linda Van Horn); Rush Medical Center, Chicago, Ill (Henry Black); Stanford Prevention Research Center, Stanford, Calif (Marcia L. Stefanick); State University of New York at Stony Brook (Dorothy Lane); Ohio State University, Columbus (Rebecca Jackson); University of Alabama, Birmingham (Cora E. Lewis); University of Arizona, Tucson/Phoenix (Tamsen Bassford); University at Buffalo, Buffalo, NY (Jean Wactawski-Wende); University of California at Davis, Sacramento (John Robbins); University of California, Irvine (F. Allan Hubbell); University of California, Los Angeles (Howard Judd); University of California at San Diego, LaJolla/Chula Vista (Robert D. Langer); University of Cincinnati, Cincinnati, Ohio (Margery Gass); University of Florida, Gainesville/Jacksonville (Marian Limacher); University of Hawaii, Honolulu (David Curb); University of Iowa, Iowa City/Davenport (Robert Wallace); University of Massachusetts/Fallon Clinic, Worcester (Judith Ockene); University of Medicine and Dentistry of New Jersey, Newark (Norman Lasser); University of Miami, Miami, Fla (Mary Jo O’Sullivan); University of Minnesota, Minneapolis (Karen Margolis); University of Nevada, Reno (Robert Brunner); University of North Carolina, Chapel Hill (Gerardo Heiss); University of Pittsburgh, Pittsburgh, Pa (Lewis Kuller); University of Tennessee, Memphis (Karen C. Johnson); University of Texas Health Science Center, San Antonio (Robert Brzyski); University of Wisconsin, Madison (Gloria E. Sarto); Wake Forest University School of Medicine, Winston-Salem, NC (Denise Bonds); Wayne State University School of Medicine/Hutzel Hospital, Detroit, Mich (Susan Hendrix).