Author Contributions: Dr Hijiya and Ms Lensing had full access of all the data in this study and take responsibility of integrity of the data and accuracy of data analysis.
Study concept and design: Hijiya, Hudson, Lensing.
Acquisition of data: Hijiya, Hudson, Lensing, Zacher, Onciu, Behm, Razzouk, Ribeiro, Rubnitz, Sandlund, Rivera, Evans, Relling, Pui.
Analysis and interpretation of data: Hijiya, Hudson, Lensing, Relling, Pui.
Drafting of the manuscript: Hijiya, Hudson, Lensing.
Critical revision of the manuscript for important intellectual content: Hijiya, Hudson, Lensing, Zacher, Onciu, Behm, Razzouk, Ribeiro, Rubnitz, Sandlund, Rivera, Evans, Relling, Pui.
Statistical analysis: Lensing.
Obtained funding: Evans, Relling, Pui.
Administrative, technical or material support: Hijiya, Hudson, Lensing, Zacher.
Study supervision: Hijiya.
Financial Disclosures: None reported.
Funding/Support: This work was supported in part by National Institutes of Health grants CA-21765, CA-51001, CA-36401, CA-78224, CA-71907, CA-60419, and GM-61393 and by the American Lebanese Syrian Associated Charities. Dr Pui is an American Cancer Society professor.
Role of the Sponsor: The funding agencies/sponsors had no involvement in the design and conduct of the study; in the collection, management, analysis, or interpretation of the data; or in the preparation, review, and approval of the manuscript.
Previous Presentation: This study was presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology, May 14, 2005, Orlando, Fla.
Acknowledgment: We thank John Gilbert for scientific editing (compensated for his work). We also thank from St Jude Children's Research Hospital: Michael Hancock, Cheng Cheng, PhD, Yinmei Zhou, Deqing Pei, and Stan Pounds, PhD, for suggestions and assistance in the statistical analysis; Joseph Khoury, MD, for discussions regarding histological classification; Annette Stone and Pam Hays for data collection; Julie Groff for assistance with figures; and Jeana Cromer for administrative assistance. We are indebted to the medical staff, the patients, and their parents for participation in the clinical trials, without whom this study would not have been possible. We dedicate this article to the late Charles Pratt, MD, who made substantial contributions in the study of subsequent malignancies in pediatric cancer survivors.