Author Contributions: Dr Mitchell had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Levy and Benjamin are both senior authors on this article.
Study concept and design: Mitchell, Vasan, Larson, D’Agostino, Levy, Benjamin.
Acquisition of data: Vasan, Wang, D’Agostino, Kannel, Benjamin.
Analysis and interpretation of data: Mitchell, Vasan, Keyes, Parise, Wang, Larson, D’Agostino, Kannel, Benjamin, Levy.
Drafting of the manuscript: Mitchell, Vasan, Parise, Levy.
Critical revision of the manuscript for important intellectual content: Mitchell, Vasan, Keyes, Wang, Larson, D’Agostino, Kannel, Levy, Benjamin.
Statistical analysis: Mitchell, Keyes, Parise, Larson, D’Agostino, Kannel, Levy.
Obtained funding: Mitchell, Vasan, Levy, Benjamin.
Administrative, technical, or material support: Mitchell, Vasan, Levy.
Study supervision: Vasan.
Financial Disclosures: Dr Levy reports that he provided consulting services for Bristol-Myers Squibb, GlaxoSmithKline, and Merck prior to 2003. No other authors reported financial disclosures.
Funding/Support: The Framingham Heart Study is funded by National Institutes of Health contract N01-HC-25195. This work was funded in part by grants R01-HL70100 and R01-HL60040 and by a grant from the Donald W. Reynolds Foundation. Dr Vasan was supported in part by grant K24-HL-04334.
Role of the Sponsor: The National Heart, Lung, and Blood Institute had no role in the study design, analyses, or drafting of the manuscript. The National Heart, Lung, and Blood Institute reviews all manuscripts submitted for publication but was not involved in the decision to publish.