Author Contributions: Dr Gretch had full access to all of the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis.
Study concept and design: Scott, Gretch.
Acquisition of data: Scott, Gretch.
Analysis and interpretation of data: Scott, Gretch.
Drafting of the manuscript: Scott, Gretch.
Critical revision of the manuscript for important intellectual content: Gretch.
Study supervision: Gretch.
Financial Disclosure: None reported.
Funding/Support: No funding was received for this review. Dr Scott reports that he is the recipient of a Mentored Patient-Oriented Research Career Development Award (K23) from the National Center for Research Resources. Dr Gretch reports that he is supported by National Institutes of Health grants AI 049168, AI 066209, and DK 92318.
Role of the Sponsor: Organizations providing salary support for the authors played no role in the design and conduct of the study, including collection, management, analysis, and interpretation of the data, and the preparation, review, and approval of the manuscript.
Acknowledgment: We thank Richard Wilson, MD, Chia Wang, MD, MSc, and Larry Corey, MD, for helpful editorial comments, all from the University of Washington and Harborview Medical Center, Seattle. None received compensation for their assistance. We also thank Georgia St. Aubyn, Harborview Medical Center, for her invaluable support in the preparation of the manuscript, whose assistance is part of her regular duties.