Author Contributions: Drs Ridker and Cook had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Ridker, Cook.
Acquisition of data: Ridker, Buring, Rifai, Cook.
Analysis and interpretation of data: Ridker, Buring, Rifai, Cook.
Drafting of the manuscript: Ridker, Cook.
Critical revision of the manuscript for important intellectual content: Ridker, Buring, Rifai, Cook.
Statistical analysis: Cook.
Obtained funding: Ridker.
Administrative, technical, or material support: Rifai.
Financial Disclosures: Dr Ridker reports that he currently or in the past 5 years has received research funding support from multiple not-for-profit entities including the National Heart, Lung, and Blood Institute, the National Cancer Institute, the American Heart Association, the Doris Duke Charitable Foundation, the Leducq Foundation, the Donald W. Reynolds Foundation, and the James and Polly Annenberg La Vea Charitable Trusts. Dr Ridker also reports that currently or in the past 5 years he has received investigator-initiated research support from multiple for-profit entities including AstraZeneca, Bayer, Bristol-Myers Squibb, Dade-Behring, Novartis, Pharmacia, Roche, Sanofi-Aventis, and Variagenics. Dr Ridker reports being listed as a coinventor on patents held by the Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease and has served as a consultant to Schering-Plough, Sanofi/Aventis, AstraZeneca, Isis Pharmaceutical, Dade-Behring, and Vascular-Biogenics. Dr Buring reports that she currently or in the past 5 years has received investigator-initiated research funding and support from the National Heart, Lung, and Blood Institute, the National Cancer Institute, the National Institute on Aging, and Dow Corning Corp; research support for pills and/or packaging from Bayer Heath Care and the Natural Source Vitamin E Association; and honoraria from Bayer for speaking engagements. Dr Rifai reports receiving research grant support from Merck Research Laboratories, serving as a consultant to Merck Research Laboratories and Sanofi/Aventis, and receiving honoraria for speaking from Merck Research Laboratories, Dade Behring, Abbott Laboratories, Ortho Diagnostics, Denka Seiken, and Roche Diagnostics. Dr Cook reports having received funding from the National Heart, Lung, and Blood Institute, the National Cancer Institute, and Roche Diagnostics, and has served as a consultant to Bayer Health Care.
Funding/Support: The Reynolds Risk Score Project was supported by investigator-initiated research grants from the Donald W. Reynolds Foundation (Las Vegas, Nev) with additional support from the Doris Duke Charitable Foundation (New York, NY), and the Leducq Foundation (Paris, France). The Women's Health Study cohort is supported by grants from the National Heart, Lung, and Blood Institute and the National Cancer Institute (Bethesda, Md).
Role of the Sponsor: The funding agencies had no involvement in the design and conduct of the study, the collection, management, analysis, and interpretation of the data, or in the drafting of the manuscript.
This article was corrected for error in data on 2/16/07, prior to publication of the correction in print.