Author Contributions: Dr Smith had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Smith, Heckbert, Lumley, Psaty.
Acquisition of data: Smith, Heckbert, Marciante, Wiggins, Psaty.
Analysis and interpretation of data: Smith, Hindorff, Heckbert, Lemaitre, Marciante, Rice, Lumley, Bis, Rosendaal.
Drafting of the manuscript: Smith.
Critical revision of the manuscript for important intellectual content: Smith, Hindorff, Heckbert, Lemaitre, Marciante, Rice, Lumley, Bis, Wiggins, Rosendaal, Psaty.
Statistical analysis: Smith, Hindorff, Rice, Lumley.
Obtained funding: Smith, Psaty.
Administrative, technical, or material support: Smith, Lemaitre, Marciante, Bis, Wiggins, Psaty.
Study supervision: Smith, Heckbert, Psaty.
Financial Disclosures: Dr Psaty has reported receiving a speaker's honorarium from Celera Diagnostics. No other authors reported financial disclosures.
Funding/Support: This study was supported by National Heart, Lung, and Blood Institute grants HL73410, HL60739, HL68639, HL43201, HL74745, and HL68986 and by National Institute on Aging grant AG09556.
Role of the Sponsors: The National Heart, Lung, and Blood Institute and the National Institute on Aging had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.