Author Contributions: Dr Mangano had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Mangano.
Acquisition of data: Vuylsteke, Juneja, Filipescu, Hoeft, Fontes, Hillel, Ott, Titov, Dietzel.
Analysis and interpretation of data: Mangano, Miao, Tudor.
Drafting of the manuscript: Mangano.
Critical revision of the manuscript for important intellectual content: Mangano, Miao, Vuylsteke, Tudor, Juneja, Filipescu, Hoeft, Fontes, Hillel, Ott, Titov, Dietzel, Levin.
Statistical analysis: Mangano, Miao, Tudor.
Obtained funding: Mangano.
Administrative, technical, or material support: Mangano, Vuylsteke, Juneja, Filipescu, Hoeft, Fontes, Hillel, Ott, Titov, Dietzel.
Study supervision: Mangano, Dietzel, Titov.
Financial Disclosures: Drs Filipescu and Fontes report receiving grants and meeting expense reimbursement from Bayer Incorporated. No other authors reported financial disclosures.
Funding/Support: The Ischemia Research and Education Foundation (IREF) funded the EPI-II in-hospital and long-term follow-up study.
Role of the Sponsor: The IREF supported data collection, including site grants, central analysis and data disposition, manuscript grants, and publication of the findings.
McSPI EPI-II In-Hospital/Long-term Study: The following institutions and individuals took part in the McSPI EPI-II study: D. Mangano, study chairman; J. Levin and L. Saidman, senior editors; P. Barash, M. Brual, C. Dietzel, A. Herskowitz, Y. Miao, T. Titov, I. C. Tudor, study design and analysis center: Ischemia Research and Education Foundation; D. Beatty, I. Lei, and B. Xavier, editorial/administrative group. United States: S. Aronson, M. Chaney, University of Chicago, Weiss Memorial Hospital; M. Comunale, Beth Israel Hospital; M. D’Ambra, Massachusetts General Hospital; R. Engelman, Baystate Medical Center; J. Fitch, F. Masud, Baylor College of Medicine; K. Grichnik, Duke Medical Center; C. B. Hantler, UTHSCSA-Audie Murphy VA, UTHSCSA-University Hospital; Z. Hillel, St. Luke's Roosevelt Hospital; M. Kanchuger and J. Ostrowski, New York University Medical Center; C. M. Mangano, Stanford University Medical Center; J. Mathew, M. Fontes, P. Barash, Yale University School of Medicine; M. McSweeney and R. Wolman, University of Wisconsin; C. A. Napolitano, University of Arkansas for Medical Sciences; L. A. Nesbitt, Discovery Alliance, Inc; N. Nijhawan, D. Warltier, VA Medical Center, Milwaukee; N. Nussmeier, Texas Heart Institute, Mercy Medical Center; E. G. Pivalizza, University of Texas Medical School, Houston; S. Polson, University of Arizona; J. Ramsay, Emory University Hospital; G. Roach, Kaiser Foundation Hospital; N. Schwann, Thomas Jefferson University Hospital, S. McNulty, N. Schwann, MCP Hahnemann University Hospital; S. Shenaq, VA Medical Center Houston; K. Shevde, Maimonides Medical Center; L. Shore-Lesserson and D. Bronheim, Mt Sinai Medical Center; J. Wahr, M. Greenfield, University of Michigan; B. Spiess, University of Washington; A. Wallace, VA Medical Center, San Francisco; Austria: H. Metzler, University of Graz; Canada: D. Ansley and J.P. O’Connor, University of British Columbia; D. Cheng, J. Karski, The Toronto Hospital; D. Côte, Laval Hospital, Quebec; P. Duke, Health Sciences Centre-University of Manitoba; J. Y. Dupuis and M. Hynes, University of Ottawa Heart Institute; B. Finegan, University of Alberta Hospital; R. Martineau and P. Couture, Montreal Heart Institute; D. Mazer, St Michael's Hospital, University of Toronto; France: C. Girard, CHRU Le Bocage; C. Isetta, Hospital Pasteur; Germany: C. A. Greim and N. Roewer, F. Kehl, Universität Würzburg; A. Hoeft, Universität Bonn; R. Loeb and J. Radke, University of Halle; T. Mollhoff, H. van Aken, Westfalische Welhelms-Universität Munster; J. Motsch and E. Martin, Universität Heidelberg; E. Ott and P. Ueberfuhr, Ludwig-Maximillians Universität; J. Scholz and P. Tonner, Universität Krankenhaus Eppendorf; H. Sonntag, Georg-August Universität Göttingen; Great Britain: D. J. R. Duthie, Glenfield Hospital; R. O. Feneck, St. Thomas' Hospital; M. A. Fox, The Cardiothoracic Centre, Liverpool; J. D. Park, South Cleveland Hospital; D. Smith, Southhampton General Hospital; A. Vohra, Manchester Royal Infirmary; A. Vuylsteke and R. D. Latimer, Papworth Hospital; Hungary: A. Szekely, Orszagos Kardiologiai Intezet; India: R. Juneja, Escorts Heart Institute; Poland: R. Pfitzner, Institute of Cardiology; Romania: D. Filipescu, Institute of Cardiology.
The following individuals and institutions did not participate in the in-hospital phase and the postdischarge phase of the EPI-II study: United States: M. Eaton, University of Rochester. The following individuals and institutions participated in the in-hospital phase but not the postdischarge phase of the EPI-II study: Colombia: J. C. Villalba and M. E. Colmenares, Fundacion Clinico Shaio; India: G. Mani, Apollo Hospital; Israel: B. Drenger, Y. Gozal, and E. Elami, Hadassah University Hospital; Italy: C. Tommasino, San Faffaelle Hospital, Universita de Milano; Mexico: P. Luna, Instituto Nacional de Cardiologia; the Netherlands: P. Roekaerts and S. DeLange; and Thailand: U. Prakanrattana, Siriraj Hospital.
Acknowledgment: We would like to express appreciation to Warren Browner, MD, MPH, California Pacific Medical Center, San Francisco, for his invaluable advice on study design and analysis. There was no financial compensation for the work of Dr Browner.