0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
From the Archives Journals |

Rapid Dissection of the Genetic Risk of Age-Related Macular Degeneration

Jonathan L. Haines, PhD; Margaret A. Pericak-Vance, PhD
JAMA. 2007;297(4):401-402. doi:10.1001/jama.297.4.401.
Text Size: A A A
Published online

Extract

Prevent Blindness America. Vision Problems in the US, 2002.Chicago, Ill: Prevent Blindness America; 2003
Klein R, Peto T, Bird A, Vannewkirk MR.The epidemiology of age-related macular degeneration. Am J Ophthalmol. 2004;137:486-495
PubMed   |  Link to Article[[XSLOpenURL/10.1016/j.ajo.2003.11.069]]
Gorin MB, Breitner JC, de Jong PT.  et al. The genetics of age-related macular degeneration. Mol Vis. 1999;5:29
PubMed
Online Mendelian Inheritance in Man (OMIM) Web site.http://www.ncbi.nlm.nih.gov/omim/. Baltimore, Md: McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine. Accessed December 27, 2006
Corder EH, Saunders AM, Strittmatter WJ.  et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923
PubMed   |  Link to Article[[XSLOpenURL/10.1126/science.8346443]]
Collins FS, Green ED, Guttmacher AE, Guyer MS.A vision for the future of genomics research. Nature. 2003;422:835-847
PubMed   |  Link to Article[[XSLOpenURL/10.1038/nature01626]]
Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, Farrer LA.Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308:421-424
PubMed   |  Link to Article[[XSLOpenURL/10.1126/science.1110189]]
Haines JL, Hauser MA, Schmidt S.  et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419-421
PubMed   |  Link to Article[[XSLOpenURL/10.1126/science.1110359]]
Hageman GS, Anderson DH, Johnson LV.  et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005;102:7227-7232
PubMed   |  Link to Article[[XSLOpenURL/10.1073/pnas.0501536102]]
Klein RJ, Zeiss C, Chew EY.  et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385-389
PubMed   |  Link to Article[[XSLOpenURL/10.1126/science.1109557]]
Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB.Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet. 2005;77:389-407
PubMed   |  Link to Article[[XSLOpenURL/10.1086/444437]]
Rivera A, Fisher SA, Fritsche LG.  et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet. 2005;14:3227-3236
PubMed   |  Link to Article[[XSLOpenURL/10.1093/hmg/ddi353]]
Schmidt S, Hauser MA, Scott WK.  et al. Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet. 2006;78:852-864
PubMed   |  Link to Article[[XSLOpenURL/10.1086/503822]]
Schaumberg DA, Hankinson SE, Guo Q, Rimm E, Hunter DJ.A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors. Arch Ophthalmol. 2007;125:55-62
Link to Article[[XSLOpenURL/10.1001/archopht.125.1.55]]
Arking DE, Pfeufer A, Post W.  et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet. 2006;38:644-651
PubMed   |  Link to Article[[XSLOpenURL/10.1038/ng1790]]
Duerr RH, Taylor KD, Brant SR.  et al. A genome-wide association study identifies il23r as an inflammatory bowel disease gene. Science. 2006;314:1461-1463
PubMed   |  Link to Article[[XSLOpenURL/10.1126/science.1135245]]
Graham RR, Kozyrev SV, Baechler EC.  et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet. 2006;38:550-555
PubMed   |  Link to Article[[XSLOpenURL/10.1038/ng1782]]

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 3

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();