Author Contributions: Dr Yusuf had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Yusuf.
Acquisition of data: Joshi, Pais, Reddy, Dorairaj, Kazmi, Pandey, Haque, Mendis, Rangarajan, Yusuf.
Analysis and interpretation of data: Joshi, Islam, Yusuf.
Drafting of the manuscript: Joshi, Islam, Yusuf.
Critical revision of the manuscript for important intellectual content: Joshi, Islam, Pais, Reddy, Dorairaj, Kazmi, Pandey, Haque, Mendis, Rangarajan, Yusuf.
Statistical analysis: Islam.
Obtained funding: Yusuf.
Administrative, technical, or material support: Rangarajan, Yusuf.
Study supervision: Rangarajan, Yusuf.
Financial Disclosures: None reported.
Funding/Support: Dr Yusuf holds an endowed chair of the Heart and Stroke Foundation of Ontario, and held a Senior Scientist Award from the Canadian Institutes of Health Research. The INTERHEART study was funded by the Canadian Institutes of Health Research; the Heart and Stroke Foundation of Ontario; the International Clinical Epidemiology Network; through unrestricted grants from AstraZeneca, Novartis, Hoechst Marion Roussel [now Sanofi-Aventis], Knoll Pharmaceuticals [now Abbott], Bristol-Myers Squibb, Sanofi-Synthelabo, King Pharma; and by funding from the following: Universidad de la Frontera, Sociedad Chilena de Cardiologia Filial Sur (Chile); Colciencias, Ministerio de Salud (Colombia); Croatian Ministry of Science & Technology; Liga Guatemalteca del Corazon (Guatemala); Astra Hassle, National Health Science Council, George Gabor Foundation (Hungary); Iran Ministry of Health; Boehringer-Ingelheim (Italy); Sankyo Pharmaceutical, Banyu Pharmaceutical, and Astra Japan; Endowment Fund for Health Development in Kuwait; ATCO Laboratories (Pakistan); Philippine Council for Health Research and Devevelopment, Pfizer Philippines Foundation, Astra Pharmacetuicals Inc, the Astra Fund for Clinical Research and Continuing Medical Education, and Pharmacia & Upjohn Inc; Foundation PROCLINICA, State Committee for Scientific Research (Poland); Singapore National Heart Association; MRC South Africa, Warner-Parke-Davis Pharmaceuticals, and Aventis (South Africa); grant from the Swedish State under LUA Agreement, Swedish Heart and Lung Foundation; the Heart Association of Thailand, Thailand Research Fund.
Role of the Sponsor: None of the sponsors played a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Acknowledgment: We thank Judy Lindeman, BA, for secretarial assistance, who was compensated for her work as part of her salary from McMaster University. We also thank the World Health Organization and the World Heart Federation for their endorsement and our friends and colleagues for help that led to the successful completion of this global study.