Author Contributions: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Eng.
Acquisition of data: Weber, Patocs.
Analysis and interpretation of data: Weber, Xu, Zhang, Patocs, Shen, Platzer, Eng.
Drafting of the manuscript: Weber, Xu, Eng.
Critical revision of the manuscript for important intellectual content: Weber, Xu, Zhang, Patocs, Shen, Platzer, Eng.
Statistical analysis: Xu, Zhang, Shen, Platzer.
Obtained funding: Eng.
Administrative, technical, or material support: Weber, Xu, Zhang, Patocs, Shen, Platzer, Eng.
Study supervision: Eng.
Financial Disclosures: Cleveland Clinic Innovations has submitted a provisional patent application based on these observations. Otherwise no other financial disclosures were reported.
Funding/Support: This study was funded in part by grant BRTT02-0003 from the state of Ohio and the Doris Duke Distinguished Clinical Scientist Award (both to Dr Eng).
Role of the Sponsor: The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation or approval of the manuscript.
Acknowledgment: We thank Kimberly Cooper, BA, Ohio State University, for technical assistance in the early aspects of this project and Carl D. Morrison, MD, Histology Core Facility, Department of Pathology, Ohio State University, Columbus, for expert opinion in evaluating the head and neck SCC tissue samples.