Author Contributions: Drs Seshadri and Beiser had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Carandang, Seshadri, Beiser, Wolf.
Acquisition of data: Seshadri, Beiser, Kelly-Hayes.
Analysis and interpretation of data: Carandang, Seshadri, Beiser, Kase, Kannel, Wolf.
Drafting of the manuscript: Carandang, Seshadri.
Critical revision of the manuscript for important intellectual content: Seshadri, Beiser, Kelly-Hayes, Kase, Kannel, Wolf.
Statistical analysis: Beiser.
Obtained funding: Wolf.
Administrative, technical, or material support: Seshadri, Kelly-Hayes, Wolf.
Study supervision: Seshadri, Kase, Wolf.
Financial Disclosures: Dr Wolf reports that he served on the data monitoring committee of a large stroke prevention trial and as chair of the PROFESS DMC trial sponsored by Boehringer-Ingelheim Ltd. No other authors reported disclosures.
Funding/Support: This study was supported by grants from the National Institute of Neurological Disorders and Stroke (5R01-NS17950) and the National Heart, Lung, and Blood Institute's Framingham Heart Study (NIH/NHLBI Contract N01-HC-25195).
Role of the Sponsors: The National Institute of Neurological Disorders and Stroke and the National Heart, Lung, and Blood Institute had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation and review of the manuscript. These sponsors did approve the manuscript as submitted.