Author Contributions: Dr L. Lange had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: L. Lange, Carlson, Durda, Nickerson, Psaty, Tracy, Reiner.
Acquisition of data: Durda, Cushman, Kuller, Psaty, Tracy, Reiner.
Analysis and interpretation of data: L. Lange, Carlson, Hindorff, E. Lange, Walston, Durda, Bis, Zeng, Lin, Kuller, Tracy, Reiner.
Drafting of the manuscript: L. Lange, Carlson, Lin, Nickerson, Reiner.
Critical revision of the manuscript for important intellectual content: L. Lange, Carlson, Hindorff, E. Lange, Walston, Durda, Cushman, Bis, Zeng, Lin, Kuller, Psaty, Tracy, Reiner.
Statistical analysis: L. Lange, Carlson, E. Lange, Zeng, Lin, Psaty, Reiner.
Obtained funding: Kuller, Nickerson, Psaty, Tracy, Reiner.
Administrative, technical, or material support: Hindorff, Durda, Kuller, Nickerson, Psaty, Tracy, Reiner.
Study supervision: Durda, Cushman, Reiner.
Financial Disclosures: None reported.
Funding/Support: This study was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103, and grant R01 HL-071862-03 (Dr Reiner) from the National Heart, Lung, and Blood Institute.
Role of the Sponsor: The funding organization participated in the design and conduct of CHS and monitored the study's data collection efforts and management. The funding organization did not participate in analysis and interpretation of the data for the manuscript but reviewed it for accuracy of the CHS study description and acknowledgment of study investigators and funding sources.
Additional Information: A full list of participating CHS investigators and institutions can be found at http://www.chs-nhlbi.org.
Acknowledgment: We thank Jill Perrotte, BS, and Kate M. Durda, Department of Pathology, University of Vermont College of Medicine, Burlington, for assistance with genotyping, and Jean Yee, BS, Department of Epidemiology, University of Washington, Seattle, for data management. All received support from the National Heart, Lung, and Blood Institute grant R01 HL-071862-03 for their contribution.