Author Contributions: Dr Marks had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Marks, Mazer, Dorey, Partin, Macairan, Nelson.
Acquisition of data: Marks, Hess, Epstein, Veltri, Makarov, Partin, Bostwick, Bostwick, Mostaghel, Nelson.
Analysis and interpretation of data: Marks, Mazer, Hess, Dorey, Veltri, Makarov, Partin, Bostwick, Mostaghel, Nelson.
Drafting of the manuscript: Marks, Dorey, Veltri, Partin, Mostaghel, Nelson.
Critical revision of the manuscript for important intellectual content: Marks, Mazer, Hess, Dorey, Epstein, Makarov, Bostwick, Bostwick, Nelson.
Statistical analysis: Marks, Dorey, Mostaghel.
Obtained funding: Marks, Partin, Bostwick, Nelson.
Administrative, technical, or material support: Marks, Mazer, Hess, Veltri, Partin, Bostwick, Bostwick, Nelson.
Study supervision: Marks, Partin, Bostwick.
Funding/Support: This study was supported by unrestricted educational grants from Watson Laboratories (Salt Lake City, Utah) and Solvay Pharmaceuticals (Marietta, Ga); National Institutes of Health/National Cancer Institute Spore grant P50CA58236 (Drs Epstein, Veltri, Makarov, and Partin); National Institutes of Health grant RR00163 (Dr Hess); the Prostate Cancer Foundation (Dr Nelson); National Institutes of Health/National Cancer Institute Spore grant CA97186; and National Institutes of Health grant DK65204 (Drs Mostaghel and Nelson).
Role of the Sponsors: No sponsor participated in the analysis or interpretation of the data, manuscript preparation, review, or approval, or the decision to publish. Dr Mazer consulted on the study design while being an employee of Watson Pharmaceuticals but resigned from the company before study completion.
Financial Disclosures: Dr Marks reported serving as a paid consultant/advisor to Solvay Pharmaceuticals and Watson Laboratories; as an investigator for Watson Laboratories in an unrelated trial; and as an investigator for Indevus. Dr Nelson reported serving as a paid consultant/advisor to Solvay Pharmaceuticals. No other authors reported financial disclosures.
Acknowledgment: Roger Rittmaster, MD, an employee of GlaxoSmithKline, provided a helpful critique of the manuscript. Dr Rittmaster did not receive additional compensation for his critique outside of his normal salary at GlaxoSmithKline. The staff of Urological Sciences Research Foundation (Shamim Baker, Peter Cheng, Anthony Cancio) provided assistance with clinical data collection, and Ilsa Coleman of Fred Hutchinson Cancer Research Center provided technical assistance with the microarray studies; all were compensated as part their normal salaries.