0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Week in JAMA |

This Week in JAMA FREE

JAMA. 2006;296(15):1809. doi:10.1001/jama.296.15.1809.
Text Size: A A A
Published online

SURVIVAL IN RECIPIENTS OF HCV-POSITIVE DONOR HEARTS

Allowing transplantation of hearts from donors with hepatitis C virus (HCV) would expand the number of available donor hearts. But, whether survival of recipients of HCV-positive donor hearts is compromised is unknown. In a retrospective study of transplant recipients, Gasink and colleaguesArticle found that receipt of an HCV-positive donor heart was associated with decreased survival vs receipt of an HCV-negative donor heart. Survival was independent of the recipient's HCV status and age. In an editorial, Qamar and RubinArticle discuss the links between viral infection, allograft injury, and graft rejection.

PREVENTING PULMONARY COMPLICATIONS AFTER CABG

In a trial of patients scheduled for elective coronary artery bypass graft (CABG) surgery and at high risk of postoperative pulmonary complications, Hulzebos and colleagues assessed the efficacy of preoperative pulmonary therapy, which included intensive inspiratory muscle training, to reduce pulmonary complications. The authors found that compared with patients who were randomly assigned to usual care, patients who received preoperative inspiratory muscle training were significantly less likely to have pulmonary complications after surgery.

EMERGENCY DEPARTMENT VISITS FOR ADVERSE DRUG EVENTS

Few studies have assessed the risk of adverse drug events (ADEs) occurring outside health care facilities. Budnitz and colleagues analyzed data from an ADE surveillance project involving 63 nationally representative hospitals to assess the burden of ADEs that resulted in emergency department visits in 2004 through 2005. The authors report there were 21 298 patients with ADEs treated in the participating emergency departments in 2004-2005 and, based on this, estimate that more than 700 000 patients were treated for ADEs in US emergency departments each year. Patient factors associated with ADEs resulting in an emergency department visit included age 65 years or older and taking a drug that typically requires ongoing monitoring.

DILATED CARDIOMYOPATHY IN CHILDREN

Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in children, but its epidemiology and clinical course are not well established. Towbin and colleagues reviewed data from 2 cohorts of children with primary DCM to advance understanding of this disease. They found a higher risk in boys than in girls, in black than in white children, and in infants than in children. Two thirds of cases were idiopathic, but important identifiable causes were myocarditis and neuromuscular disease. Outcomes were influenced by age, heart failure status at diagnosis, and cause.

NESIRITIDE USE AFTER PUBLICATION OF ADVERSE EVENT DATA

Whether publication of data suggesting an approved medication is associated with adverse events influences clinical practice is unknown. To investigate this question, Hauptman and colleagues assessed the use of nesiritide and other intravenous vasoactive therapies among patients with decompensated heart failure at 491 hospitals before and after data were published, suggesting that increased risks of renal failure and mortality are associated with nesiritide. They found that nesiritide use decreased sharply after publication of data that questioned its safety.

A PIECE OF MY MIND

“Hope is an enduring source of fortitude, courage, and, on some level, ingenuity in the face of adversity.” From “Hope Is the Thing With Feathers.”

MEDICAL NEWS & PERSPECTIVES

The first genome-wide scans of breast and colorectal cancer cells have revealed new insights into the genetic causes of these diseases.

CLINICIAN'S CORNER

Despite the presence of methylmercury and other contaminants in some fish, the potential health benefits of modest fish intake (1-2 servings per week) exceed the potential risks among adults.

AUTHOR IN THE ROOM TELECONFERENCE

Join David Spiros, MD, MPH, October 18, 2006, from 2 to 3 PM eastern time to discuss wait-and-see prescription for otitis media. To register, go to http://www.ihi.org/AuthorintheRoom.

AUDIO COMMENTARY

Dr DeAngelis summarizes and comments on this week's issue. Go to http://jama.ama-assn.org/misc/audiocommentary.dtl.

JAMA PATIENT PAGE

For your patients: Information about eating fish: health benefits and risks.

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...