Author Contributions: Mr Hulzebos had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Hulzebos, Helders, Brutel de la Rievere, Van Meeteren.
Acquisition of data: Hulzebos, Favié, Van Meeteren.
Analysis and interpretation of data: Hulzebos, Helders, De Bie, Van Meeteren.
Drafting of the manuscript: Hulzebos, Favié, Van Meeteren.
Critical revision of the manuscript for important intellectual content: Helders, De Bie, Brutel de la Rievere, Van Meeteren.
Statistical analysis: Hulzebos, De Bie, Van Meeteren.
Obtained funding: Hulzebos, Van Meeteren.
Administrative, technical, or material support: Hulzebos, Favié.
Study supervision: Helders, Brutel de la Rievere, Van Meeteren.
Financial Disclosures: None reported.
Funding/Support: This study was funded by a project grant 1310.0004 from the Netherlands Organization for Health Research and Development; the Rudolf Magnus Institute of Neuroscience of the University Medical Center Utrecht, Utrecht, the Netherlands; Agis Health Insurance House, Amersfoort; and the Royal Dutch Association of Physical Therapy. PT-Medical, the Netherlands, supplied the inspiratory threshold loading devices.
Role of the Sponsors: The funding agencies and suppliers had no role in study design, data collection, data analysis, data interpretation, writing of the manuscript, or the decision to submit the manuscript for publication. PT-Medical also had no role in the financial funding of the study or salaries of support staff, grants, and gifts.
Acknowledgment: We thank J. Cor Kalkman, MD, PhD, Jan van Klarenbosch, MD, MSc, Hans Wesenhagen, MD, MSc, Department of Anesthesiology, and Jan-Willem Lammers, MD, PhD, Department of Pulmonary Diseases, for their comments and suggestions. We also thank Ada Gigengack-Baars and Kim Jalink, Department of Hospital Hygiene and Infection Prevention, for their registration of nosocomial infections; and our external investigator, Anske van der Bom, MD, PhD, Clinical Epidemiologist, Julius Center for Health Sciences and Primary Care, University Medical Center, for her contribution in patient allocation. None of the persons named received compensation for their contribution.