Author Contributions: Drs Towbin and Sleeper had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Towbin, Colan, Lurie, Lipshultz.
Acquisition of data: Towbin, Colan, Clunie, Messere, Hsu, Canter, Lipshultz.
Analysis and interpretation of data: Towbin, Lowe, Colan, Sleeper, Orav, Cox, Lurie, Hsu, Canter, Wilkinson, Lipshultz.
Drafting of the manuscript: Towbin, Lowe, Colan, Sleeper, Lipshultz.
Critical revision of the manuscript for important intellectual content: Lowe, Colan, Sleeper, Orav, Clunie, Messere, Cox, Lurie, Hsu, Canter, Wilkinson, Lipshultz.
Statistical analysis: Lowe, Sleeper, Orav, Lipshultz.
Obtained funding: Towbin, Colan, Lurie, Lipshultz.
Administrative, technical, or material support: Colan, Clunie, Messere, Wilkinson, Lipshultz.
Study supervision: Towbin, Colan, Sleeper, Lipshultz.
Financial Disclosures: None reported.
Funding/Support: This study was supported by National Heart, Lung, and Blood Institute (NHLBI) grant R01 HL53392. The PCMR is supported by a grant funded by the NHLBI (grant R01 HL53392 to Dr Lipshultz, principal investigator). The work is also funded in part by grants from the National Institutes of Health (grants P01 HL67155 to Dr Towbin and R01 HL78522, R01 HL72705, R01 CA79060, P01 CA68484, and N01 HR96041 to Dr Lipshultz), Parker Family Foundation (to Dr Lipshultz), the John Patrick Albright Foundation (to Dr Towbin), Abby Glaser Children's Heart Fund (to Dr Towbin), the Amanda McPherson Foundation (to Dr Towbin), Glover-Crask Trust (to Dr Lipshultz), Perini Quality of Life Program (to Dr Lipshultz), Lance Armstrong Foundation (to Dr Lipshultz), and the Children's Cardiomyopathy Foundation (to Dr Lipshultz). Dr Towbin is supported by the Texas Children's Hospital Foundation Chair in Pediatric Cardiac Research. The University of Miami serves as the PCMR Administrative Coordinating Center, with Texas Children's Hospital, Houston, and Children's Hospital, Boston, serving as regional clinical coordinating centers. The New England Research Institutes is the data and statistical coordinating center. An NHLBI-appointed observational study monitoring board assists in data monitoring.
Role of the Sponsors: The NHLBI provided oversight of the study with an independent observational study monitoring board, but neither the NHLBI nor any other funders had any role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Acknowledgment: We thank the participating clinical centers for patient recruitment and Tom Lang, MA, professional medical editor, Tom Lang Communications and Training, for editorial assistance. Mr Lang was compensated for his presubmittal editorial review of the manuscript.