Published Online: September 12, 2006 (doi:10.1001/jama.296.13.jrv60011).
Author Contributions: Dr Henry had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: McGettigan, Henry.
Acquisition of data: McGettigan.
Analysis and interpretation of data: McGettigan, Henry.
Drafting of the manuscript: McGettigan, Henry.
Critical revision of the manuscript for important intellectual content: McGettigan, Henry.
Statistical analysis: McGettigan, Henry.
Obtained funding: McGettigan, Henry.
Administrative, technical, or material support: McGettigan.
Study supervision: Henry.
Financial Disclosures: Drs McGettigan and Henry report that they are separately conducting a case-control study to examine the clinical and genetic determinants of risk of cardiovascular events with use of NSAIDS and COX-2 inhibitors. The study is funded by the National Health and Medical Research Council and Heart Foundation of Australia. The genetic component of the study looks at polymorphisms of the COX-2 gene and also at aspirin resistance polymorphisms. They also report that the laboratory that is working with this effort plans to enter a contract with Pfizer to support the laboratory work.There is currently no contract and the money will not come into Dr McGettigan or Dr Henry's department or the University of Newcastle. The staff in the genetics laboratory are not involved in the systematic review.
Funding/Support: Funding for the review was provided through project grants from the National Health and Medical Research Council of Australia (252469) and the National Heart Foundation Australia (G 05S 1980).
Role of Sponsor: The funding organizations had no role in the design, conduct, analysis, or reporting of the results of this study; the collection, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.
Acknowledgment: We would like to acknowledge the invaluable assistance of Danielle Anthony, BS, who undertook the original literature searches and retrieval of published articles for this review. Ms Anthony received no additional compensation besides salary from the University of Newcastle.