Author Contributions: Dr Rodríguez had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Rodríguez, Sethi, Cheruvu, Kitahata, Deeks, Lederman.
Acquisition of data: Rodríguez, Boswell, Mathews, Bangsberg, Martin, Yadavalli, Deeks, Lederman.
Analysis and interpretation of data: Rodríguez, Sethi, Cheruvu, Mackay, Bosch, Kitahata, Bangsberg, Whalen, Sieg, Lederman.
Drafting of the manuscript: Rodríguez, Sethi, Cheruvu, Sieg, Lederman.
Critical revision of the manuscript for important intellectual content: Rodríguez, Sethi, Cheruvu, Mackay, Bosch, Kitahata, Boswell, Mathews, Bangsberg, Martin, Whalen, Yadavalli, Deeks, Lederman.
Statistical analysis: Rodríguez, Sethi, Cheruvu, Mackay, Bosch, Martin, Whalen.
Obtained funding: Lederman.
Administrative, technical, or material support: Rodríguez, Boswell, Bangsberg, Whalen, Sieg, Deeks, Lederman.
Study supervision: Rodríguez, Sethi.
Drs Rodríguez and Sethi and Mr Cheruvu contributed equally to this work.
Financial Disclosures: None reported.
Funding/Support: This work was supported in part by the Case Western Reserve University Center for AIDS Research and NIH grants AI36219 and MH54907.
Role of the Sponsors: The funding sources had no role in the choice of methods, the contents or form of this work, or the decision to submit the results for publication.
Acknowledgment: We thank John Spritzler, ScD, for his advice and assistance in the calculation of confidence intervals for the coefficients of determination reported herein, and Victor DeGruttola, ScD, and Rui Wang, MS, for their assistance in devising the statistical approach used in this study. We also thank Donna Mildvan, MD, for critical review of the revised manuscript and valuable suggestions regarding clinical applications of the work and the members of the Cleveland Immunopathogenesis Consortium for valuable input and discussions about the implications of the data. None of these collaborators received any form of compensation for their input.