Author Contributions: Dr Chen had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Chen, Wang, S. Lee, Watson, Gruber, Euhus, Kinzler, Parmigiani.
Acquisition of data: Nafa, J. Lee, Romans, Watson, Gruber, Jass, Gallinger, Lindor, Casey, Ellis, Giardiello.
Analysis and interpretation of data: Chen, Wang, S. Lee, Watson, Gruber, Ellis, Giardiello, Parmigiani.
Drafting of the manuscript: Chen, Romans, Gruber, Giardiello, Parmigiani.
Critical revision of the manuscript for important intellectual content: Chen, Wang, S. Lee, Nafa, J. Lee, Watson, Gruber, Euhus, Kinzler, Jass, Gallinger, Lindor, Casey, Ellis, Giardiello, Parmigiani.
Statistical analysis: Chen, S. Lee, Parmigiani.
Obtained funding: Kinzler, Jass, Gallinger, Lindor, Parmigiani.
Administrative, technical, or material support: Nafa, J. Lee, Romans, Gruber, Euhus, Giardiello.
Study supervision: Chen, Gruber, Giardiello, Parmigiani.
Financial Disclosures: None reported.
Funding/Support: This research was supported by Johns Hopkins SPORE in Gastrointestinal Cancer grant P50CA62924; National Cancer Institute (NCI) grant R01CA105090; the Cancer Research Foundation of America; the John G. Rangos, Sr, Charitable Foundation; the Clayton Fund; the Niehaus-Southworth-Weissenbach Research Fund; and the Evan Frankel Fellowship. The work of the Colon Cancer Family Registry (Colon CFR) is supported by the NCI, National Institutes of Health, under Request for Applications No. CA-96-001 and through cooperative agreements with member of the Colon CFR and principal investigators.
Disclaimer: The content of this article does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the Colon CFR, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the Colon CFR.
Acknowledgment: We thank John Hopper, PhD, and Mark Jenkins, PhD, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Victoria, Australia, for providing unpublished details about their article23 and Amanda Blackford, MSc, Sidney Kimmel Comprehensive Cancer Center, for assistance with data analysis. Drs Hopper and Jenkins received no compensation for their contributions; Ms Blackford's work is supported by Johns Hopkins SPORE in Gastrointestinal Cancer grant P50CA62924.