Author Contributions: Dr Balmaña had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Balmaña and Stockwell contributed equally to this work.
Study concept and design: Balmaña, Stockwell, Deffenbaugh, Syngal.
Acquisition of data: Deffenbaugh, Ward, Scholl, Tazelaar, Burbidge, Syngal.
Analysis and interpretation of data: Balmaña, Stockwell, Steyerberg, Stoffel, Deffenbaugh, Reid, Scholl, Hendrickson, Syngal.
Drafting of the manuscript: Balmaña, Stockwell, Steyerberg, Syngal.
Critical revision of the manuscript for important intellectual content: Balmaña, Stockwell, Steyerberg, Stoffel, Deffenbaugh, Reid, Ward, Scholl, Hendrickson, Tazelaar, Burbidge, Syngal.
Statistical analysis: Balmaña, Stockwell, Steyerberg, Stoffel, Reid.
Obtained funding: Syngal.
Administrative, technical, or material support: Deffenbaugh, Ward, Scholl, Hendrickson, Tazelaar, Burbidge, Syngal.
Study supervision: Balmaña, Deffenbaugh, Scholl, Syngal.
Financial Disclosures: Dr Stoffel reports having received lecture honoraria from Myriad Genetics Laboratories Inc; Dr Syngal reports having received lecture honoraria from and having served on a clinical advisory board for Myriad Genetics Laboratories Inc; and Mss Deffenbaugh, Reid, and Burbidge, Drs Ward, Scholl, and Tazelaar, and Mr Hendrickson were employed by Myriad Genetics Laboratories Inc when the study was conducted. No other disclosures were reported.
Funding/Support: Dr Balmaña was supported by a grant from La Caixa, Barcelona, Spain, Dr Steyerberg by grants from the Trust Fund Erasmus University Rotterdam and a Marx Fellowship from Dana-Farber Cancer Institute, Dr Stoffel from a Junior Faculty Career Development Award from the American College of Gastroenterology, and Dr Syngal by National Institutes of Health/National Cancer Institute grant K24 CA 113433. No grant support was obtained from Myriad Genetics Laboratories Inc to support the study.
Role of the Sponsor: The funding sources played no role in the design and conduct of the study; collection, management, analysis, and interpretation of data; or preparation, review, or approval of the manuscript.
Acknowledgment: We thank Meredith Regan, ScD, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, for her assistance in data preparation; Jimmy L. Dias, BA, and William B. Dilworth, BA, Interactive Communications, Dana-Farber Cancer Institute, for their technical assistance in the Web-based model development; and Beth M. Ford, BA, Medical Oncology, Dana-Farber Cancer Institute, for her assistance in data collection and administrative issues. None of those listed herein received compensation for their work.