Author Contributions: Dr Moss had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Hobbs, Peterson, Moss, McNitt, Zareba, Kaufman, Towbin, Vincent.
Acquisition of data: Moss, McNitt, Zareba, Qi, Robinson, Benhorin, Kaufman, Napolitano, Priori, Towbin, Vincent.
Analysis and interpretation of data: Hobbs, Peterson, Moss, McNitt, Zareba, Goldenberg, Qi, Sauer, Ackerman, Benhorin, Locati, Towbin, Vincent, Zhang.
Drafting of the manuscript: Hobbs, Peterson, Moss, Towbin.
Critical revision of the manuscript for important intellectual content: Hobbs, Peterson, Moss, McNitt, Zareba, Goldenberg, Qi, Robinson, Sauer, Ackerman, Benhorin, Kaufman, Locati, Napolitano, Priori, Towbin, Vincent, Zhang.
Statistical analysis: Hobbs, Peterson, Moss, McNitt, Zareba, Benhorin, Locati.
Obtained funding: Moss, Towbin.
Administrative, technical, or material support: Moss, Qi, Robinson, Sauer, Towbin, Vincent.
Study supervision: Moss, Goldenberg, Towbin.
Financial Disclosures: The University of Rochester (Dr Moss) received a grant from Genaissance Pharmaceuticals that supported research for detection of LQTS-related ion-channel mutations. Dr Ackerman reports that he is a consultant for Clinical Data (formerly Genaissance Pharmaceuticals) with respect to the FAMILION genetic test for cardiac ion-channel mutations and holds significant interest in intellectual property related to ion-channel patents. Dr Priori reports that she has a patent pending for a screening algorithm for genetic testing in LQTS. No other financial disclosures were reported.
Funding/Support: This work was supported by research grants HL-33843 and HL-51618 from the National Institutes of Health, Bethesda, Md, and by a research grant to the University of Rochester from Genaissance Pharmaceuticals.
Role of the Sponsor: The funding organizations did not participate in the design and conduct of the study, or in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.