Author Contributions: Dr Mills had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Mills, Nachega, Orbinski, Attaran, Rachlis, Wilson, Guyatt, Bangsberg.
Acquisition of data: Mills, Nachega, Rachlis, Wu, Bangsberg.
Analysis and interpretation of data: Mills, Nachega, Buchan, Singh, Rachlis, Wu, Cooper, Thabane, Guyatt, Bangsberg.
Drafting of the manuscript: Mills, Nachega, Buchan, Orbinski, Attaran, Singh, Rachlis, Cooper, Guyatt, Bangsberg.
Critical revision of the manuscript for important intellectual content: Mills, Nachega, Buchan, Orbinski, Attaran, Singh, Rachlis, Wu, Cooper, Thabane, Wilson, Guyatt, Bangsberg.
Statistical analysis: Mills, Nachega, Buchan, Rachlis, Wu, Cooper, Thabane, Guyatt.
Obtained funding: Mills.
Administrative, technical, or material support: Mills, Singh, Rachlis, Guyatt, Bangsberg.
Study supervision: Mills, Nachega, Orbinski, Wilson, Guyatt, Bangsberg.
Financial Disclosures: Dr Nachega received grant support or funding, honoraria (including honoraria for continuing medical education), travel grants, and lecture sponsorships from GlaxoSmithKline, Bristol-Myers Squibb, and Aspen Pharmaceuticals.
Funding/Support: Dr Mills is supported by the Ontario HIV Treatment Network and the Canadian Institutes for Health Research. Dr Nachega is supported by grants AI005535901 and K23A106858201 from the US National Institutes of Health. Dr Wilson is supported by the Canadian Institutes for Health Research. Dr Bangsberg is supported by grants AA015287, MH54907, and AI27763 from the US National Institutes of Health and by the Doris Duke Charitable Foundation. The Ontario HIV Treatment Network provided financial support for this study.
Role of the Sponsor: The agencies had no role in the conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Acknowledgment: We thank Pearl Raju, PhD (Centre for International Health and Human Rights Studies, Toronto, Ontario), and Dugald Seely, ND, MSc (University of Toronto, Toronto, Ontario), for assistance with searching and arbitration. They did not receive compensation for their work. We also thank the authors of the original studies for assistance and clarifications.