Since March 1, 2005, an increasing number of cases of contact lens–associated Fusarium keratitis have been reported in Singapore. Khor and colleagues reviewed all cases of Fusarium keratitis diagnosed in Singapore during the period from March 1, 2005, to May 26, 2006, involving individuals who wore contact lenses to correct a refractive error. Sixty-six patients were identified with Fusarium keratitis. Among the 66 patients, 65 patients wore soft, disposable contact lenses and 62 patients reported using one brand of contact lens cleaning solution. Poor lens hygiene practices and wearing lenses past the replacement date were additional factors reported by patients with Fusarium infection.