We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Grand Rounds | Clinician's Corner

Depression and Cardiovascular Disease Healing the Broken-Hearted

Mary A. Whooley, MD
JAMA. 2006;295(24):2874-2881. doi:10.1001/jama.295.24.2874.
Text Size: A A A
Published online

Major depressive disorder is a risk factor for the development of incident coronary heart disease events in healthy patients and for adverse cardiovascular outcomes in patients with established heart disease. Depression is present in 1 of 5 outpatients with coronary heart disease and in 1 of 3 outpatients with congestive heart failure, yet the majority of cases are not recognized or appropriately treated. It is not known whether treating depression improves cardiovascular outcomes, but antidepressant treatment with selective serotonin reuptake inhibitors is generally safe, alleviates depression, and improves quality of life. This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?


Figure 1. Diagnosing Depression in Patients With Heart Disease
Graphic Jump Location
Figure 2. The 9-Item Patient Health Questionnaire Depression Screening Instrument
Graphic Jump Location

The PHQ-9 copyright 1999 Pfizer Inc. All rights reserved. Reproduced with permission. Use of the PHQ-9 may be made in accordance with the terms of use available at http://www.pfizer.com/pfizer/phq-9/index-jsp.




You need to register in order to view this quiz.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles