Author Contributions: Dr Loeb had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Loeb, Walter, Krueger, Simor, Marrie.
Acquisition of data: Loeb, Goeree, Brazil, Moss.
Analysis and interpretation of data: Loeb, Carusone, Goeree, Walter, Brazil.
Drafting of the manuscript: Loeb, Carusone, Goeree, Walter, Brazil.
Critical revision of the manuscript for important intellectual content: Loeb, Carusone, Goeree, Walter, Brazil, Krueger, Simor, Moss, Marrie.
Statistical analysis: Loeb, Carusone, Goeree, Walter.
Obtained funding: Loeb, Brazil, Krueger, Simor.
Administrative, technical, or material support: Simor, Moss.
Study supervision: Loeb, Moss.
Financial Disclosures: Dr Loeb reported serving on an advisory board for Bayer Canada. Dr Simor reported serving on advisory boards and speaking for Bayer Canada. Dr Marrie reported receiving research funding from Jannsen Ortho, Pfizer, and Bristol-Myers Squibb. No other authors reported financial disclosures.
Funding/Support: This study was supported by a Canadian Institutes of Health Research Interdisciplinary Health Research Team grant and by the Physicians' Services Incorporated Foundation of Ontario. Dr Loeb was supported by a Canadian Institutes of Health Research New Investigator Award, a Premier's Research Excellence Award (Ontario Ministry of Health and Long-term Care), and an Arthur Bond Scholarship.
Role of the Sponsors: The funding agencies played no role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Acknowledgment: We thank Allan Detsky, MD, PhD, Department of Medicine, University of Toronto, Toronto, Ontario, and Brian Haynes, MD, PhD, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, for their helpful comments about the manuscript. Drs Detsky and Haynes did not receive any compensation for their reviews. We are indebted to the research study nurses and nursing home staff who participated in this study.