Author Contributions: Dr Singh had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Singh, Turner, Bernstein.
Acquisition of data: Singh, Turner, Xue.
Analysis and interpretation of data: Singh, Turner, Xue, Targownik, Bernstein.
Drafting of the manuscript: Singh.
Critical revision of the manuscript for important intellectual content: Singh, Turner, Xue, Targownik, Bernstein.
Statistical analysis: Singh, Turner, Xue.
Obtained funding: Turner, Bernstein.
Administrative, technical, or material support: Turner.
Study supervision: Turner, Bernstein.
Financial Disclosures: None reported.
Funding/Support: This work was supported in part by an unrestricted educational grant from AstraZeneca Canada. Dr Bernstein is supported in part by a Canadian Institutes of Health Research Investigator Award and by a Crohn's and Colitis Foundation of Canada Research Scientist Award. Dr Targownik is supported by the Rudy Falk Clinician Scientist Award.
Role of the Sponsors: AstraZeneca Canada had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Acknowledgment: We thank David Lieberman, MD, Division of Gastroenterology, Oregon Health and Science University and Portland VA Medical Center, Portland, for his thoughtful review of this article.