Author Contributions: Drs Bongartz and Matteson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bongartz, Matteson, Montori, Sutton, Sweeting, Buchan.
Acquisition of data: Bongartz, Matteson.
Analysis and interpretation of data: Bongartz, Matteson, Montori, Sutton, Sweeting, Buchan.
Drafting of the manuscript: Bongartz, Matteson, Montori.
Critical revision of the manuscript for important intellectual content: Bongartz, Matteson, Montori, Sutton, Sweeting, Buchan.
Statistical analysis: Sutton, Sweeting, Buchan.
Financial Disclosures: Dr Bongartz and Dr Matteson report having been paid consultants for Abbott for work unrelated to this study. No other disclosures were reported.
Funding/Support: This study was supported by the Mayo Foundation. Additional data were provided by Abbott and Centocor and were subject to a confidentiality agreement.
Role of the Sponsors: Abbott and Centocor received the manuscript 4 weeks prior to submission but did not have any role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.