We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Managing Small Thyroid Cancers

Ernest L. Mazzaferri, MD
JAMA. 2006;295(18):2179-2182. doi:10.1001/jama.295.18.2179.
Text Size: A A A
Published online


The management of thyroid nodules poses several diagnostic dilemmas. The vast majority of thyroid nodules are asymptomatic and impalpable, such that only 4% to 7% of the adult US population has palpable thyroid nodules.1 However, neck ultrasonography reveals a large reservoir of clinically silent impalpable nodules, termed incidentalomas, the prevalence of which (both benign and malignant) ranges from 30% to 60% in autopsy studies and from 19% to 67% in prospective clinical studies.2 Thyroid nodules increase in prevalence with advancing age and are more prevalent in women. An ultrasound screening study of 96 278 German employees aged 18 to 65 years found that the presence of a thyroid nodule was 13% in women and 9% in men aged 26 to 35 years, increasing to almost 45% in women and 32% in men aged 55 years and older.3 Moreover, thyroid cancer, which is relatively rare, is found in approximately 4% of fine-needle aspiration biopsy (FNAB) cytology specimens, will account for 30 000 new cases in the United States in 2006,2 and, while usually associated with a good prognosis, will cause about 1500 deaths this year.4

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

63 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles