Author Contributions: Dr Nelson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Nelson, Vesco, Haney, Nedrow, Miller, Humphrey.
Acquisition of data: Nelson, Vesco, Haney, Nedrow, Miller, Walker, Humphrey.
Analysis and interpretation of data: Nelson, Vesco, Haney, Fu, Nedrow, Miller, Nicolaidis, Humphrey.
Drafting of the manuscript: Nelson, Vesco, Haney, Fu, Nedrow, Miller, Walker.
Critical revision of the manuscript for important intellectual content: Nelson, Vesco, Fu, Nedrow, Miller, Nicolaidis, Humphrey.
Statistical analysis: Nelson, Fu.
Obtained funding: Nelson.
Administrative, technical, or material support: Nelson, Walker.
Study supervision: Nelson, Humphrey.
Financial Disclosures: Dr Haney reported being involved in clinical trials for Sanofi-Synthelabo and Pfizer prior to work on this systemic review, none of which involved any drugs mentioned in this article, any treatments for hot flashes, or other menopausal symptoms. No other authors reported financial disclosures.
Funding/Support: The National Institutes of Health (NIH) Office of Medical Applications of Research funded this research through the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Centers Program for the NIH sponsored State of the Science Conference on Managing Menopause-Related Symptoms (290-02-0024, Task Order No. 5, Rockville, Md). Additional support came from the Portland Veterans Affairs Medical Center Women's Health Fellowship.
Role of the Sponsor: NIH and AHRQ staff and content experts critically reviewed an earlier draft of the manuscript that did not include any meta-analysis. The AHRQ staff reviewed a later draft of the manuscript prior to journal submission. Neither review resulted in major modifications. The authors are responsible for the content of the manuscript and the decision to submit it for publication.
Acknowledgment: We thank Christina Bougatsos, BS, research assistant, Andrew Hamilton, MLS, MS, research librarian, Laurie Hoyt Huffman, MS, research associate, and Peggy Nygren, MA, research associate, all affiliated with the Oregon Health and Science University, Portland, for their contributions to this project. All individuals mentioned received compensation for their work.