Author Contributions: Dr Yan and Ms Colangelo had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Yan, Liu, Daviglus, Greenland.
Acquisition of data: Liu, Sidney.
Analysis and interpretation of data: Yan, Liu, Daviglus, Colangelo, Kiefe, Matthews, Greenland.
Drafting of the manuscript: Yan.
Critical revision of the manuscript for important intellectual content: Yan, Liu, Daviglus, Colangelo, Kiefe, Sidney, Matthews, Greenland.
Statistical analysis: Yan, Liu, Colangelo.
Obtained funding: Liu, Sidney.
Administrative, technical, or material support: Yan, Daviglus, Matthews, Greenland.
Study supervision: Yan, Daviglus.
Financial Disclosures: None reported.
Funding/Support: This study was funded by grants N01-HC-48047 through N01-HC-48050 and N01-HC-95095 from the National Heart, Lung, and Blood Institute, National Institutes of Health.
Role of the Sponsor: The National Heart, Lung, and Blood Institute participated in the design and conduct of the CARDIA study, in the collection of the data, and in the review and approval of the manuscript. The Institute did not participate in the analysis or interpretation of the data, or in the preparation of the manuscript.