Author Contributions: Dr Weissman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Weissman, Pilowsky, Wickramaratne, Wisniewski, Fava, Garber, Trivedi, Rush.
Acquisition of data: Weissman, Pilowsky, Hughes, Garber, Malloy, King, Cerda, Sood, Alpert, Trivedi.
Analysis and interpretation of data: Weissman, Wickramaratne, Talati, Fava, Rush.
Drafting of the manuscript: Weissman, Talati, Rush.
Critical revision of the manuscript for important intellectual content: Weissman, Pilowsky, Wickramaratne, Talati, Wisniewski, Fava, Hughes, Garber, Malloy, King, Cerda, Sood, Alpert, Trivedi, Rush.
Statistical analysis: Wickramaratne, Talati, Fava.
Obtained funding: Weissman.
Administrative, technical, or material support: Pilowsky, Hughes, Malloy, King, Trivedi, Rush.
Study supervision: Weissman, Pilowsky, Wisniewski, Hughes, Garber, King, Cerda, Alpert, Trivedi, Rush.
Financial Disclosures: Dr Weissman has received grant support from Eli Lilly and GlaxoSmithKline and has served as a scientific advisor to Eli Lilly. Dr Fava has received research support from Abbott Laboratories, Lichtwer Pharma GmbH, Lorex Pharmaceuticals; received honoraria from Bayer AG, Compellis, Janssen Pharmaceutica, Knoll Pharmaceutical Co, Lundbeck, Dov Pharmaceuticals, Biovail Pharmaceuticals Inc, BrainCells, Grunenthal GmBH, Sepracor, and Somerset Pharmaceuticals; and received both research support and honoraria from Aspect Medical Systems, AstraZeneca, Bristol-Myers Squibb, Cephalon, Eli Lilly & Co, Forest Pharmaceutials, GlaxoSmithKline, J&J Pharmaceuticals, Novartis, Organon Inc, Pharmavite, Pfizer Inc, Roche, Sanofi/Synthelabo, Solvay Pharmaceuticals, and Wyeth-Ayerst Laboratories. Dr Hughes has received support from Healthcare Technology Systems Inc and GlaxoSmithKline. Dr Sood serves on the speaker's bureau of AstraZeneca. Dr Trivedi has served as a consultant or has advised for Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, Wyeth-Ayerst laboratories, Sepracor, Johnson & Johnson, Cyberonics, and Pfizer; received lecture fees from Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, Wyeth-Ayerst Laboratories, and Cyberonics; received grant support from the National Institutes of Health, National Institute of Mental Health, Bristol-Myers Squibb, Cephalon Inc, Predix, Pfizer/Parexel, and Corcept Therapeutics Inc. Dr Rush has received speaking honoraria from and provided scientific consultation to Forest Laboratories. None of the other authors reported disclosures.
Funding/Support: This study was supported by grants R01MH063852 (Dr Weissman, principal investigator) and N01 MH90003 (Dr Rush, principal investigator) from the National Institute of Mental Health. Dr Garber was supported in part by an Independent Scientist Award K02 MH66249 from the National Institute of Mental Health. We appreciate the support of Forest Laboratories for providing citalopram at no cost.
Role of the Sponsor: Funding sources played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
STAR*D Regional Centers: Massachusetts General Hospital, Boston, Andrew Nierenberg, MD; University of California, San Diego, Sid Zisook, MD; University of Michigan, Ann Arbor, Elizabeth Young, MD; University of North Carolina, Chapel Hill, Bradley Gaynes, MD, MPH; University of Texas Southwestern Medical Center, Dallas, Mustafa Husain, MD; Vanderbilt University, Nashville, Tenn, Steven Hollon, PhD; and Virginia Commonwealth University, Richmond, Susan Kornstein, MD.
Disclaimer: The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services nor does mention of trade names, commercial products, or organizations imply endorsement by the US government.
Acknowledgment: We thank Huaiyu Yang, MD, and Michele Candrian, MS, Boston, Mass; Rachel N. Swan, MS, Mi Wu, BS, and Liz Ezell, MA, Nashville, Tenn; Julie Linker, PhD, Richmond, Va; Graham J. Emslie, MD, Jeanne Rintelmann, BA, and Laurie Macleod, RN, CCRC, Dallas, Tex; Elizabeth Santana, marriage and family therapy intern, San Diego; Ann Brewster, PhD, Joanne DeVeaugh-Geiss, MA, LPA, and Renee White, MSW, Chapel Hill, NC; Melissa Webster, MSW, and Brooke Tracey, BS, Ann Arbor, Mich; and Diane Warden, PhD, and Kathy Shores-Wilson, PhD, at the National Coordinating Center.