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JAMA. 2006;295(11):E1-E6. doi:10.1001/jama.295.11.E1.
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Published online

eTable 1 Late-Breaking Trials Included in This Study

eTable 1 Late-Breaking Trials Included in This Study (cont)

Table Graphic Jump LocationeTable 1. Late-Breaking Trials Included in This Study

Table Graphic Jump LocationeTable 1. Late-Breaking Trials Included in This Study (cont)
Bertrand ME, Rupprecht H-J, Urban P.  et al.  Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: clopidogrel aspirin stent international cooperative (CLASSICS) trial.  Circulation. 2000;102:624-629
PubMed   |  Link to Article
Buxton AE, Lee KL, Fisher JD.  et al.  A randomized study of the prevention of sudden death in patients with coronary artery disease.  N Engl J Med. 1999;341:1882-1890
PubMed   |  Link to Article
Cannon CP, McCabe CH, Wilcox RG.  et al.  Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial.  Circulation. 2000;102:149-156
PubMed   |  Link to Article
Henry TD, Annex BH, McKendall GR.  et al.  The VIVA Trial: vascular endothelial growth factor in ischemia for vascular angiogenesis.  Circulation. 2003;107:1359-1365
PubMed   |  Link to Article
Hjalmarson A, Goldstein S, Fagerberg B.  et al. and the MERIT-HF Study Group.  Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF).  JAMA. 2000;283:1295-1302
PubMed   |  Link to Article
Hochman JS, Sleeper LA, Webb JG.  et al.  Early revascularization in acute myocardial infarction complicated by cardiogenic shock.  N Engl J Med. 1999;341:625-634
PubMed   |  Link to Article
Montalescot G, Barragan P, Wittenberg O.  et al.  Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction.  N Engl J Med. 2001;344:1895-1903
PubMed   |  Link to Article
Neuhaus K, Braunwald E, Antman E.  et al.  Intravenous nPA for the treatment of infarcting myocardium early: InTime-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction.  Eur Heart J. 2000;21:2005-2013
PubMed   |  Link to Article
Oesterle SN, Sanborn TA, Ali N.  et al.  Percutaneous transmyocardial laser revascularization for severe angina: the PACIFIC randomised trial.  Lancet. 2000;356:1705-1710
PubMed   |  Link to Article
O'Neill WW, Serruys P, Knudtson M.  et al.  Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization.  N Engl J Med. 2000;342:1316-1324
PubMed   |  Link to Article
Teo KK, Burton JR, Buller CE.  et al.  Long term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: the simvastatin/enalapril coronary atherosclerosis trial (SCAT).  Circulation. 2000;102:1748-1754
PubMed   |  Link to Article
Theroux P, Chaitman BR, Danchin N.  et al.  Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations: main results of the GUARDIAN trial.  Circulation. 2000;102:3032-3038
PubMed   |  Link to Article
Valagussa F, Franzosi MG, Geraci E.  et al.  Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial (Gruppo Italiano per lo studio della sopravvivenza nell'infarto (GISSI) prevention study).  Lancet. 1999;354:447-455
PubMed   |  Link to Article
Van de Werf F, Ardissino D, Armstrong PW.  et al.  Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT 2 double-blind randomised trial: assessment of safety and efficacy of a new thrombolytic (ASSENT-2).  Lancet. 1999;354:716-722
PubMed   |  Link to Article
Wallentin L, Lagerqvist B, Husted S.  et al.  Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial.  Lancet. 2000;356:9-16
PubMed   |  Link to Article
Wallentin L, Swahn E, Kontny F.  et al.  Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study.  Lancet. 1999;354:701-707
PubMed   |  Link to Article
Weaver WD, Reisman MA, Griffin JJ.  et al.  Optimum percutaneous transluminal coronary angioplasty compared with routine stent strategy (OPUS-1) a randomised trial.  Lancet. 2000;355:2199-2203
PubMed   |  Link to Article
Akkerhuis KM, Neuhaus K-L, Wilcox RG.  et al.  Safety and preliminary efficacy of a one-month treatment with glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation (FROST).  Eur Heart J. 2000;21:2042-2055
PubMed   |  Link to Article
Connolly SJ, Cybulsky L, Lamy A.  et al.  Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-blocker length of stay (BLOS) study.  Am Heart J. 2003;145:226-232
PubMed   |  Link to Article
Coussement PK, Bassand J-P, Convens C.  et al.  A synthetic factor-Xa inhibitor (ORG31540/SR90107A) as an adjunct to fibrinolysis in acute myocardial infarction: the PENTALYSE study.  Eur Heart J. 2001;22:1716-1724
PubMed   |  Link to Article
Furberg CD, Wright JT, Davis BR.  et al.  Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid lowering treatment to prevent heart attack (ALLHAT) trial.  JAMA. 2000;283:1967-1975
PubMed   |  Link to Article
Alderman EL, Brooks MM, Bourassa M.  et al.  Seven-year outcome in bypass angioplasty revascularization investigation (BARI) by treatment and diabetic status.  J Am Coll Cardiol. 2000;35:1122-1129
PubMed   |  Link to Article
Cuffe MS, Califf RM, Adams KF Jr.  et al.  Short term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial.  JAMA. 2002;287:1541-1547
PubMed   |  Link to Article
Mukherjee D, Mahaffey KW, Moliterno DJ.  et al.  Promise of combined low-molecular-weight heparin and platelet glycoproetin IIb/IIIa inhibition: results from platelet IIb/IIIa antagonist for the reduction of acute coronary syndrome events in global organization network B (PARAGON B).  Am Heart J. 2002;144:995-1002
PubMed   |  Link to Article
Herrington DM, Reboussin DM, Brosnihan KB.  et al.  Effects of estrogen replacement on the progression of coronary-artery atherosclerosis.  N Engl J Med. 2000;343:522-529
PubMed   |  Link to Article
Kastrati A, Schomig A, Dirschinger J.  et al.  A randomized trial comparing stenting with balloon angioplasty in small vessels in patients with symptomatic coronary artery disease.  Circulation. 2000;102:2593-2598
PubMed   |  Link to Article
Klein AL, Grimm RA, Murray RD.  et al.  Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation.  N Engl J Med. 2001;344:1411-1420
PubMed   |  Link to Article
Koning R, Eltchaninoff H, Commeau P.  et al.  Stent placement compared with balloon angioplasty for small coronary arteries: in-hospital and six-month clinical and angiographic results.  Circulation. 2001;104:1604-1608
PubMed   |  Link to Article
Neumann F-J, Kastrati A, Miethke T.  et al.  Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebo-controlled trial.  Lancet. 2001;357:2085-2089
PubMed   |  Link to Article
Newby L.and the K–Second Symphony Investigators.  Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes.  Circulation. 2001;103:1727-1733
PubMed   |  Link to Article
Whitlow PL, DeMaio SJ, Perin EC.  et al.  One-year results of percutaneous myocardial revascularization for refractory angina pectoris.  Am J Cardiol. 2003;91:1342-1346
PubMed   |  Link to Article
Popma JJ, Suntharalingam M, Lansky AJ.  et al.  Randomized trial of 90Sr/90Y beta-radiation versus placebo control for treatment in-stent restenosis.  Circulation. 2002;106:1090-1096
PubMed   |  Link to Article
Hammermeister K, Sethi GK, Henderson WG.  et al.  Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial.  J Am Coll Cardiol. 2000;36:1152-1158
PubMed   |  Link to Article
Ross AM, Molhoek P, Lundergan C.  et al.  Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: second trial of heparin and aspirin reperfusion therapy (HART-II).  Circulation. 2001;104:648-652
PubMed   |  Link to Article
Saul JP, Ross B, Schaffer MS.  et al.  Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia.  Clin Pharmacol Ther. 2001;69:145-157
PubMed   |  Link to Article
Simons M, Annex BH, Laham RJ.  et al.  Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial.  Circulation. 2002;105:788-793
PubMed   |  Link to Article
Tcheng JE, O’Shea JC, Cohen EA.  et al.  Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomized, placebo-controlled trial.  Lancet. 2000;356:2037-2044
PubMed   |  Link to Article
Waksman R, Cheneau E, Ajani AE.  et al.  Intracoronary radiation therapy improves the clinical and angiographic outcomes of diffuse in-stent restenotic lesions: results of the Washington radiation for in-stent restenosis trial for long lesions (Long WRIST) studies.  Circulation. 2003;107:1744-1749
PubMed   |  Link to Article
Zeymer U, Uebis R, Vogt A.  et al.  Randomized comparison of percutaneous transluminal coronary angioplasty and medical therapy in stable survivors of acute myocardial infarction with single vessel disease: a study of the arbeitsgemeinschaft leitende kardiologische krankenhausarzte.  Circulation. 2003;108:1324-1328
PubMed   |  Link to Article
Abraham WT, Fisher WG, Smith AL.  et al.  Cardiac resynchronization in chronic heart failure.  N Engl J Med. 2002;346:1845-1853
PubMed   |  Link to Article
Simoons ML, Krzeminska-Pakula M, Alonso A.  et al.  Improved reperfusion and clinical outcome with enoxaparin as an adjunct to streptokinase thrombolysis in acute myocardial infarction: the AMI-SK study.  Eur Heart J. 2002;23:1282-1290
PubMed   |  Link to Article
Bansch D, Antz M, Boczor S.  et al.  Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the cardiomyopathy trial (CAT).  Circulation. 2002;105:1453-1458
PubMed   |  Link to Article
Barrett-Connor E, Grady D, Sashegyi A.  et al.  Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (multiple outcomes of raloxifene evaluation) randomized trial.  JAMA. 2002;287:847-857
PubMed   |  Link to Article
Carlsson J, Miketic S, Windeler J.  et al.  Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the strategies of treatment of atrial fibrillation (STAF) study.  J Am Coll Cardiol. 2003;41:1690-1696
PubMed   |  Link to Article
Alfonso F, Zueco J, Cequier A.  et al.  A randomized comparison of repeat stenting with balloon angioplasty in patients with in-stent restenosis.  J Am Coll Cardiol. 2003;42:796-805
PubMed   |  Link to Article
Dargie H, Colucci W, Ford I.  et al.  Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.  Lancet. 2001;357:1385-1390
PubMed   |  Link to Article
Eisenberg MJ, Blankenship JC, Huynh T.  et al.  Evaluation of routine functional testing after percutaneous coronary intervention.  Am J Cardiol. 2004;93:744-747
PubMed   |  Link to Article
Grines CL, Watkins MW, Helmer G.  et al.  Angiogenic gene therapy (AGENT) trial in patients with stable angina pectoris.  Circulation. 2002;105:1291-1297
PubMed   |  Link to Article
Hueb W, Soares PR, Gersh BJ.  et al.  The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results.  J Am Coll Cardiol. 2004;43:1743-1751
PubMed   |  Link to Article
Kass D, Shapiro EP, Kawaguchi M.  et al.  Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.  Circulation. 2001;104:1464-1470
PubMed   |  Link to Article
Knudtson ML, Wyse DG, Galbraith PD.  et al.  Chelation therapy for ischemic heart disease: a randomized controlled trial.  JAMA. 2002;287:481-486
PubMed   |  Link to Article
Lederman RJ, Mendelsohn FO, Anderson RD.  et al.  Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial.  Lancet. 2002;359:2053-2058
PubMed   |  Link to Article
Oemrawsingh PV, Mintz GS, Schalij MJ.  et al.  Intravascular ultrasound guidance improves angiographic and clinical outcome of stent implantation for long coronary artery stenoses: final results of a randomized comparison with angiographic guidance (TULIP study).  Circulation. 2003;107:62-67
PubMed   |  Link to Article
Packer M, Coats AJS, Fowler MB.  et al.  Effect of carvedilol on survival in severe chronic heart failure.  N Engl J Med. 2001;344:1651-1658
PubMed   |  Link to Article
Albert MA, Danielson E, Rifai N.  et al.  Effect of statin therapy on c-reactive protein levels: the pravastatin inflammation/crp evaluation (PRINCE): a randomized trial and cohort study.  JAMA. 2001;286:64-70
PubMed   |  Link to Article
Saksena S, Prakash A, Ziegler P.  et al.  Improved suppression of recurrent atrial fibrillation with dual-site right atrial pacing and antiarrhythmic drug therapy.  J Am Coll Cardiol. 2002;40:1140-1150
PubMed   |  Link to Article
Sigwart U, Stables RH, Booth J.  et al.  Coronary artery bypass surgery versus percutaneous coronary intervention with stent implantation in patients with multivessel coronary artery disease (the Stent or Surgery trial): a randomised controlled trial.  Lancet. 2002;360:965-970
PubMed   |  Link to Article
Torre-Amione G, Young JB, Colucci WS.  et al.  Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure.  J Am Coll Cardiol. 2003;42:140-147
PubMed   |  Link to Article
Waksman R, Ajani AE, White RL.  et al.  Intravascular gamma radiation for in-stent restenosis in saphenous-vein bypass grafts.  N Engl J Med. 2002;346:1194-1199
PubMed   |  Link to Article
Mahoney EM, Jurkovitz CT, Chu H.  et al.  Cost and cost-effectiveness of an early invasive vs conservative strategy for the treatment of unstable angina and non-ST-segment elevation myocardial infarction.  JAMA. 2002;288:1851-1858
PubMed   |  Link to Article
Yusuf S, Zhao F, Mehta SR.  et al.  Effect of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.  N Engl J Med. 2001;345:494-502
PubMed   |  Link to Article
Andersen HR, Nielson TT, Rasmussen K.  et al.  A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction.  N Engl J Med. 2003;349:733-742
PubMed   |  Link to Article
Cercek B, Shah PK, Noc M.  et al.  Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndromes in the azithromycin in acute coronary syndrome (AZACS) trial: a randomised controlled trial.  Lancet. 2003;361:809-813
PubMed   |  Link to Article
Stankovic G, Colombo A, Bersin R.  et al.  Comparison of directional coronary atherectomy and stenting versus stenting alone for the treatment of de novo and restenotic coronary artery narrowing.  Am J Cardiol. 2004;93:953-958
PubMed   |  Link to Article
Dahlof B, Devereux RB, Kjeldsen SE.  et al.  Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomised trial against atenelol.  Lancet. 2002;359:995-1003
PubMed   |  Link to Article
Goodman SG, Fitchett D, Armstrong PW.  et al.  Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide.  Circulation. 2003;107:238-244
PubMed   |  Link to Article
Haude M, Konorza TFM, Kalnins U.  et al.  Heparin-coated stent placement for the treatment of stenoses in small coronary arteries of symptomatic patients.  Circulation. 2003;107:1265-1270
PubMed   |  Link to Article
McCullough PA, Nowak RM, McCord J.  et al.  B-type natriuretic peptide and clinical judgement in emergency diagnosis of heart failure: analysis from breathing not properly (BNP) multinational study.  Circulation. 2002;106:416-422
PubMed   |  Link to Article
Moss AJ, Zareba W, Hall WJ.  et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.  N Engl J Med. 2002;346:877-883
PubMed   |  Link to Article
O'Connor CM, Dunne MW, Pfeffer MA.  et al.  Azithromycin for the secondary prevention of coronary heart disease events: the WIZARD study: a randomized controlled trial.  JAMA. 2003;290:1459-1466
PubMed   |  Link to Article
Packer M, Califf RM, Konstam MA.  et al.  Comparison of omapatrilat and enalapril in patients with chronic heart failure: the omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE).  Circulation. 2002;106:920-926
PubMed   |  Link to Article
Phillips M, Boehmer JP, Cataneo RN.  et al.  Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study).  J Heart Lung Transplant. 2004;23:701-708
PubMed   |  Link to Article
Pitt B, Reichek N, Willenbrock R.  et al.  Effect of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study.  Circulation. 2003;108:1831-1838
PubMed   |  Link to Article
Ross AM, Gibbons RJ, Stone GW.  et al.  A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II).  J Am Coll Cardiol. 2005;45:1775-1780
PubMed   |  Link to Article
Pache J, Kastrati A, Mehilli J.  et al.  Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial.  J Am Coll Cardiol. 2003;41:1283-1288
PubMed   |  Link to Article
Serruys PWJC, de Feyter P, Macaya C.  et al.  Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial.  JAMA. 2002;287:3215-3222
PubMed   |  Link to Article
Stevenson LW, Miller LW, Desvigne-Nickens P.  et al.  Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (randomized evaluation of mechanical assistance in treatment of chronic hear failure).  Circulation. 2004;110:975-981
PubMed   |  Link to Article
Wyse DG, Waldo AL, DiMarco JP.  et al.  A comparison of rate control and rhythm control in patients with atrial fibrillation.  N Engl J Med. 2002;347:1825-1833
PubMed   |  Link to Article
Young JB, Abraham WT, Smith AL.  et al.  Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial.  JAMA. 2003;289:2685-2694
PubMed   |  Link to Article

Figures

Tables

Table Graphic Jump LocationeTable 1. Late-Breaking Trials Included in This Study
Table Graphic Jump LocationeTable 1. Late-Breaking Trials Included in This Study (cont)

References

Bertrand ME, Rupprecht H-J, Urban P.  et al.  Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: clopidogrel aspirin stent international cooperative (CLASSICS) trial.  Circulation. 2000;102:624-629
PubMed   |  Link to Article
Buxton AE, Lee KL, Fisher JD.  et al.  A randomized study of the prevention of sudden death in patients with coronary artery disease.  N Engl J Med. 1999;341:1882-1890
PubMed   |  Link to Article
Cannon CP, McCabe CH, Wilcox RG.  et al.  Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial.  Circulation. 2000;102:149-156
PubMed   |  Link to Article
Henry TD, Annex BH, McKendall GR.  et al.  The VIVA Trial: vascular endothelial growth factor in ischemia for vascular angiogenesis.  Circulation. 2003;107:1359-1365
PubMed   |  Link to Article
Hjalmarson A, Goldstein S, Fagerberg B.  et al. and the MERIT-HF Study Group.  Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF).  JAMA. 2000;283:1295-1302
PubMed   |  Link to Article
Hochman JS, Sleeper LA, Webb JG.  et al.  Early revascularization in acute myocardial infarction complicated by cardiogenic shock.  N Engl J Med. 1999;341:625-634
PubMed   |  Link to Article
Montalescot G, Barragan P, Wittenberg O.  et al.  Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction.  N Engl J Med. 2001;344:1895-1903
PubMed   |  Link to Article
Neuhaus K, Braunwald E, Antman E.  et al.  Intravenous nPA for the treatment of infarcting myocardium early: InTime-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction.  Eur Heart J. 2000;21:2005-2013
PubMed   |  Link to Article
Oesterle SN, Sanborn TA, Ali N.  et al.  Percutaneous transmyocardial laser revascularization for severe angina: the PACIFIC randomised trial.  Lancet. 2000;356:1705-1710
PubMed   |  Link to Article
O'Neill WW, Serruys P, Knudtson M.  et al.  Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization.  N Engl J Med. 2000;342:1316-1324
PubMed   |  Link to Article
Teo KK, Burton JR, Buller CE.  et al.  Long term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: the simvastatin/enalapril coronary atherosclerosis trial (SCAT).  Circulation. 2000;102:1748-1754
PubMed   |  Link to Article
Theroux P, Chaitman BR, Danchin N.  et al.  Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations: main results of the GUARDIAN trial.  Circulation. 2000;102:3032-3038
PubMed   |  Link to Article
Valagussa F, Franzosi MG, Geraci E.  et al.  Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial (Gruppo Italiano per lo studio della sopravvivenza nell'infarto (GISSI) prevention study).  Lancet. 1999;354:447-455
PubMed   |  Link to Article
Van de Werf F, Ardissino D, Armstrong PW.  et al.  Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT 2 double-blind randomised trial: assessment of safety and efficacy of a new thrombolytic (ASSENT-2).  Lancet. 1999;354:716-722
PubMed   |  Link to Article
Wallentin L, Lagerqvist B, Husted S.  et al.  Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial.  Lancet. 2000;356:9-16
PubMed   |  Link to Article
Wallentin L, Swahn E, Kontny F.  et al.  Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study.  Lancet. 1999;354:701-707
PubMed   |  Link to Article
Weaver WD, Reisman MA, Griffin JJ.  et al.  Optimum percutaneous transluminal coronary angioplasty compared with routine stent strategy (OPUS-1) a randomised trial.  Lancet. 2000;355:2199-2203
PubMed   |  Link to Article
Akkerhuis KM, Neuhaus K-L, Wilcox RG.  et al.  Safety and preliminary efficacy of a one-month treatment with glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation (FROST).  Eur Heart J. 2000;21:2042-2055
PubMed   |  Link to Article
Connolly SJ, Cybulsky L, Lamy A.  et al.  Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-blocker length of stay (BLOS) study.  Am Heart J. 2003;145:226-232
PubMed   |  Link to Article
Coussement PK, Bassand J-P, Convens C.  et al.  A synthetic factor-Xa inhibitor (ORG31540/SR90107A) as an adjunct to fibrinolysis in acute myocardial infarction: the PENTALYSE study.  Eur Heart J. 2001;22:1716-1724
PubMed   |  Link to Article
Furberg CD, Wright JT, Davis BR.  et al.  Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid lowering treatment to prevent heart attack (ALLHAT) trial.  JAMA. 2000;283:1967-1975
PubMed   |  Link to Article
Alderman EL, Brooks MM, Bourassa M.  et al.  Seven-year outcome in bypass angioplasty revascularization investigation (BARI) by treatment and diabetic status.  J Am Coll Cardiol. 2000;35:1122-1129
PubMed   |  Link to Article
Cuffe MS, Califf RM, Adams KF Jr.  et al.  Short term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial.  JAMA. 2002;287:1541-1547
PubMed   |  Link to Article
Mukherjee D, Mahaffey KW, Moliterno DJ.  et al.  Promise of combined low-molecular-weight heparin and platelet glycoproetin IIb/IIIa inhibition: results from platelet IIb/IIIa antagonist for the reduction of acute coronary syndrome events in global organization network B (PARAGON B).  Am Heart J. 2002;144:995-1002
PubMed   |  Link to Article
Herrington DM, Reboussin DM, Brosnihan KB.  et al.  Effects of estrogen replacement on the progression of coronary-artery atherosclerosis.  N Engl J Med. 2000;343:522-529
PubMed   |  Link to Article
Kastrati A, Schomig A, Dirschinger J.  et al.  A randomized trial comparing stenting with balloon angioplasty in small vessels in patients with symptomatic coronary artery disease.  Circulation. 2000;102:2593-2598
PubMed   |  Link to Article
Klein AL, Grimm RA, Murray RD.  et al.  Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation.  N Engl J Med. 2001;344:1411-1420
PubMed   |  Link to Article
Koning R, Eltchaninoff H, Commeau P.  et al.  Stent placement compared with balloon angioplasty for small coronary arteries: in-hospital and six-month clinical and angiographic results.  Circulation. 2001;104:1604-1608
PubMed   |  Link to Article
Neumann F-J, Kastrati A, Miethke T.  et al.  Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebo-controlled trial.  Lancet. 2001;357:2085-2089
PubMed   |  Link to Article
Newby L.and the K–Second Symphony Investigators.  Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes.  Circulation. 2001;103:1727-1733
PubMed   |  Link to Article
Whitlow PL, DeMaio SJ, Perin EC.  et al.  One-year results of percutaneous myocardial revascularization for refractory angina pectoris.  Am J Cardiol. 2003;91:1342-1346
PubMed   |  Link to Article
Popma JJ, Suntharalingam M, Lansky AJ.  et al.  Randomized trial of 90Sr/90Y beta-radiation versus placebo control for treatment in-stent restenosis.  Circulation. 2002;106:1090-1096
PubMed   |  Link to Article
Hammermeister K, Sethi GK, Henderson WG.  et al.  Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial.  J Am Coll Cardiol. 2000;36:1152-1158
PubMed   |  Link to Article
Ross AM, Molhoek P, Lundergan C.  et al.  Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: second trial of heparin and aspirin reperfusion therapy (HART-II).  Circulation. 2001;104:648-652
PubMed   |  Link to Article
Saul JP, Ross B, Schaffer MS.  et al.  Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia.  Clin Pharmacol Ther. 2001;69:145-157
PubMed   |  Link to Article
Simons M, Annex BH, Laham RJ.  et al.  Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial.  Circulation. 2002;105:788-793
PubMed   |  Link to Article
Tcheng JE, O’Shea JC, Cohen EA.  et al.  Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomized, placebo-controlled trial.  Lancet. 2000;356:2037-2044
PubMed   |  Link to Article
Waksman R, Cheneau E, Ajani AE.  et al.  Intracoronary radiation therapy improves the clinical and angiographic outcomes of diffuse in-stent restenotic lesions: results of the Washington radiation for in-stent restenosis trial for long lesions (Long WRIST) studies.  Circulation. 2003;107:1744-1749
PubMed   |  Link to Article
Zeymer U, Uebis R, Vogt A.  et al.  Randomized comparison of percutaneous transluminal coronary angioplasty and medical therapy in stable survivors of acute myocardial infarction with single vessel disease: a study of the arbeitsgemeinschaft leitende kardiologische krankenhausarzte.  Circulation. 2003;108:1324-1328
PubMed   |  Link to Article
Abraham WT, Fisher WG, Smith AL.  et al.  Cardiac resynchronization in chronic heart failure.  N Engl J Med. 2002;346:1845-1853
PubMed   |  Link to Article
Simoons ML, Krzeminska-Pakula M, Alonso A.  et al.  Improved reperfusion and clinical outcome with enoxaparin as an adjunct to streptokinase thrombolysis in acute myocardial infarction: the AMI-SK study.  Eur Heart J. 2002;23:1282-1290
PubMed   |  Link to Article
Bansch D, Antz M, Boczor S.  et al.  Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the cardiomyopathy trial (CAT).  Circulation. 2002;105:1453-1458
PubMed   |  Link to Article
Barrett-Connor E, Grady D, Sashegyi A.  et al.  Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (multiple outcomes of raloxifene evaluation) randomized trial.  JAMA. 2002;287:847-857
PubMed   |  Link to Article
Carlsson J, Miketic S, Windeler J.  et al.  Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the strategies of treatment of atrial fibrillation (STAF) study.  J Am Coll Cardiol. 2003;41:1690-1696
PubMed   |  Link to Article
Alfonso F, Zueco J, Cequier A.  et al.  A randomized comparison of repeat stenting with balloon angioplasty in patients with in-stent restenosis.  J Am Coll Cardiol. 2003;42:796-805
PubMed   |  Link to Article
Dargie H, Colucci W, Ford I.  et al.  Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.  Lancet. 2001;357:1385-1390
PubMed   |  Link to Article
Eisenberg MJ, Blankenship JC, Huynh T.  et al.  Evaluation of routine functional testing after percutaneous coronary intervention.  Am J Cardiol. 2004;93:744-747
PubMed   |  Link to Article
Grines CL, Watkins MW, Helmer G.  et al.  Angiogenic gene therapy (AGENT) trial in patients with stable angina pectoris.  Circulation. 2002;105:1291-1297
PubMed   |  Link to Article
Hueb W, Soares PR, Gersh BJ.  et al.  The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results.  J Am Coll Cardiol. 2004;43:1743-1751
PubMed   |  Link to Article
Kass D, Shapiro EP, Kawaguchi M.  et al.  Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.  Circulation. 2001;104:1464-1470
PubMed   |  Link to Article
Knudtson ML, Wyse DG, Galbraith PD.  et al.  Chelation therapy for ischemic heart disease: a randomized controlled trial.  JAMA. 2002;287:481-486
PubMed   |  Link to Article
Lederman RJ, Mendelsohn FO, Anderson RD.  et al.  Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial.  Lancet. 2002;359:2053-2058
PubMed   |  Link to Article
Oemrawsingh PV, Mintz GS, Schalij MJ.  et al.  Intravascular ultrasound guidance improves angiographic and clinical outcome of stent implantation for long coronary artery stenoses: final results of a randomized comparison with angiographic guidance (TULIP study).  Circulation. 2003;107:62-67
PubMed   |  Link to Article
Packer M, Coats AJS, Fowler MB.  et al.  Effect of carvedilol on survival in severe chronic heart failure.  N Engl J Med. 2001;344:1651-1658
PubMed   |  Link to Article
Albert MA, Danielson E, Rifai N.  et al.  Effect of statin therapy on c-reactive protein levels: the pravastatin inflammation/crp evaluation (PRINCE): a randomized trial and cohort study.  JAMA. 2001;286:64-70
PubMed   |  Link to Article
Saksena S, Prakash A, Ziegler P.  et al.  Improved suppression of recurrent atrial fibrillation with dual-site right atrial pacing and antiarrhythmic drug therapy.  J Am Coll Cardiol. 2002;40:1140-1150
PubMed   |  Link to Article
Sigwart U, Stables RH, Booth J.  et al.  Coronary artery bypass surgery versus percutaneous coronary intervention with stent implantation in patients with multivessel coronary artery disease (the Stent or Surgery trial): a randomised controlled trial.  Lancet. 2002;360:965-970
PubMed   |  Link to Article
Torre-Amione G, Young JB, Colucci WS.  et al.  Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure.  J Am Coll Cardiol. 2003;42:140-147
PubMed   |  Link to Article
Waksman R, Ajani AE, White RL.  et al.  Intravascular gamma radiation for in-stent restenosis in saphenous-vein bypass grafts.  N Engl J Med. 2002;346:1194-1199
PubMed   |  Link to Article
Mahoney EM, Jurkovitz CT, Chu H.  et al.  Cost and cost-effectiveness of an early invasive vs conservative strategy for the treatment of unstable angina and non-ST-segment elevation myocardial infarction.  JAMA. 2002;288:1851-1858
PubMed   |  Link to Article
Yusuf S, Zhao F, Mehta SR.  et al.  Effect of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.  N Engl J Med. 2001;345:494-502
PubMed   |  Link to Article
Andersen HR, Nielson TT, Rasmussen K.  et al.  A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction.  N Engl J Med. 2003;349:733-742
PubMed   |  Link to Article
Cercek B, Shah PK, Noc M.  et al.  Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndromes in the azithromycin in acute coronary syndrome (AZACS) trial: a randomised controlled trial.  Lancet. 2003;361:809-813
PubMed   |  Link to Article
Stankovic G, Colombo A, Bersin R.  et al.  Comparison of directional coronary atherectomy and stenting versus stenting alone for the treatment of de novo and restenotic coronary artery narrowing.  Am J Cardiol. 2004;93:953-958
PubMed   |  Link to Article
Dahlof B, Devereux RB, Kjeldsen SE.  et al.  Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomised trial against atenelol.  Lancet. 2002;359:995-1003
PubMed   |  Link to Article
Goodman SG, Fitchett D, Armstrong PW.  et al.  Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide.  Circulation. 2003;107:238-244
PubMed   |  Link to Article
Haude M, Konorza TFM, Kalnins U.  et al.  Heparin-coated stent placement for the treatment of stenoses in small coronary arteries of symptomatic patients.  Circulation. 2003;107:1265-1270
PubMed   |  Link to Article
McCullough PA, Nowak RM, McCord J.  et al.  B-type natriuretic peptide and clinical judgement in emergency diagnosis of heart failure: analysis from breathing not properly (BNP) multinational study.  Circulation. 2002;106:416-422
PubMed   |  Link to Article
Moss AJ, Zareba W, Hall WJ.  et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.  N Engl J Med. 2002;346:877-883
PubMed   |  Link to Article
O'Connor CM, Dunne MW, Pfeffer MA.  et al.  Azithromycin for the secondary prevention of coronary heart disease events: the WIZARD study: a randomized controlled trial.  JAMA. 2003;290:1459-1466
PubMed   |  Link to Article
Packer M, Califf RM, Konstam MA.  et al.  Comparison of omapatrilat and enalapril in patients with chronic heart failure: the omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE).  Circulation. 2002;106:920-926
PubMed   |  Link to Article
Phillips M, Boehmer JP, Cataneo RN.  et al.  Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study).  J Heart Lung Transplant. 2004;23:701-708
PubMed   |  Link to Article
Pitt B, Reichek N, Willenbrock R.  et al.  Effect of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study.  Circulation. 2003;108:1831-1838
PubMed   |  Link to Article
Ross AM, Gibbons RJ, Stone GW.  et al.  A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II).  J Am Coll Cardiol. 2005;45:1775-1780
PubMed   |  Link to Article
Pache J, Kastrati A, Mehilli J.  et al.  Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial.  J Am Coll Cardiol. 2003;41:1283-1288
PubMed   |  Link to Article
Serruys PWJC, de Feyter P, Macaya C.  et al.  Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial.  JAMA. 2002;287:3215-3222
PubMed   |  Link to Article
Stevenson LW, Miller LW, Desvigne-Nickens P.  et al.  Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (randomized evaluation of mechanical assistance in treatment of chronic hear failure).  Circulation. 2004;110:975-981
PubMed   |  Link to Article
Wyse DG, Waldo AL, DiMarco JP.  et al.  A comparison of rate control and rhythm control in patients with atrial fibrillation.  N Engl J Med. 2002;347:1825-1833
PubMed   |  Link to Article
Young JB, Abraham WT, Smith AL.  et al.  Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial.  JAMA. 2003;289:2685-2694
PubMed   |  Link to Article
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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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