The design of the classic, parallel-group randomized trial involves formulating a null hypothesis of no difference between 2 interventions and identifying a clinically relevant difference (Δ) that researchers do not wish to overlook. Commonly referred to as superiority trials, the investigators usually hope to be able to reject the null hypothesis and demonstrate a difference between interventions. In contrast, a noninferiority trial is one-sided in nature1 as it seeks to determine whether a new intervention is no worse than a reference intervention within a prespecified noninferiority interval (−Δ to 0) for the primary outcome. Similarly, an equivalence trial aims to determine whether 2 interventions have a similar effect, within a prespecified interval (−Δ to + Δ).
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 52
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Care at the Close of Life EDUCATION GUIDES
Overcoming the False Dichotomy of Curative vs Palliative Care for Late-Stage HIV/AIDS
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.