The design of the classic, parallel-group randomized trial involves formulating a null hypothesis of no difference between 2 interventions and identifying a clinically relevant difference (Δ) that researchers do not wish to overlook. Commonly referred to as superiority trials, the investigators usually hope to be able to reject the null hypothesis and demonstrate a difference between interventions. In contrast, a noninferiority trial is one-sided in nature1 as it seeks to determine whether a new intervention is no worse than a reference intervention within a prespecified noninferiority interval (−Δ to 0) for the primary outcome. Similarly, an equivalence trial aims to determine whether 2 interventions have a similar effect, within a prespecified interval (−Δ to + Δ).
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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Care at the Close of Life EDUCATION GUIDESOvercoming the False Dichotomy of Curative vs Palliative Care for Late-Stage HIV/AIDS
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