Author Contributions: Dr Arnold had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Cappola, Fried, Danese, Burke, Tracy, Ladenson.
Acquisition of data: Fried, Kuller, Burke, Tracy, Ladenson.
Analysis and interpretation of data: Cappola, Fried, Arnold, Danese, Kuller, Burke, Tracy, Ladenson.
Drafting of the manuscript: Cappola, Arnold.
Critical revision of the manuscript for important intellectual content: Cappola, Fried, Danese, Kuller, Burke, Tracy, Ladenson.
Statistical analysis: Arnold, Danese.
Obtained funding: Fried, Kuller, Burke, Tracy, Ladenson.
Administrative, technical, or material support: Cappola, Kuller, Tracy, Ladenson.
Study supervision: Cappola, Fried, Ladenson.
Financial Disclosures: None reported.
CHS Investigators: A complete list of participating CHS investigators and institutions can be found at http://www.chs-nhlbi.org.
Funding/Support: This study was supported by an American Heart Association Grant-in-Aid (to Dr Fried) with funding from July 1991 to June 1993. The research reported in this article was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from the National Heart, Lung, and Blood Institute (NHLBI). Dr Cappola is supported by grant K23-AG19161 from the National Institute on Aging.
Role of the Sponsor: This study was funded through contracts with the NHLBI and included substantial NHLBI involvement in study design and oversight. A member of the NHLBI serves on the executive committee of the study, and NHLBI reviews all manuscripts prior to publication.