The global burden of influenza infection is staggering. In a typical
year, approximately 20% of the world's population is infected and more than
a half million individuals die of influenza-associated complications.1 During influenza pandemics, morbidity and mortality
are catastrophic—20 million to 100 million individuals died in the 1918
influenza pandemic, 2 million in the 1955 pandemic, and 1 million in the 1968
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