The introduction of methods of neonatal intensive care in the 1960s and 1970s led to significant improvements in the survival and neurodevelopmental outcomes of preterm infants. By the late 1970s, 65% of infants born with very low birth weight (VLBW, <1500 g) and 40% of those of extremely low birth weight (ELBW, <1000 g) survived,1 of whom 70% to 90% were reported to be without serious impairment during early childhood.1 However, additional problems became evident during the school age and adolescent years. When compared with term-born children, preterm children demonstrated poorer cognitive function and academic performance; more behavioral problems, mainly hyperactivity and attentional weaknesses but also shy and withdrawn behavior; problems with social skills; and anxiety and depression.2 Chronic health problems were also more prevalent and included those problems associated with cerebral palsy, asthma, and visual and hearing impairments. These developmental, behavioral, and health problems led to concern as to how the children would function as they approached adulthood.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 11
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
Table 9.2-2 Refuted Evidence From Studies of Physiologic or Surrogate Endpoints
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.