Author Contributions: Dr Connolly had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Connolly, Dorian, Roberts, Gent, Fain, Talajic, Hohnloser.
Acquisition of data: Connolly, Dorian, Gent, Bailin, Champagne, Talajic, Coutu, Gronefeld, Hohnloser.
Analysis and interpretation of data: Connolly, Dorian, Roberts, Gent, Thorpe, Talajic, Gronefeld, Hohnloser.
Drafting of the manuscript: Connolly, Dorian, Roberts, Gent, Bailin.
Critical revision of the manuscript for important intellectual content: Connolly, Dorian, Roberts, Gent, Fain, Thorpe, Champagne, Talajic, Coutu, Gronefeld, Hohnloser.
Statistical analysis: Connolly, Roberts, Gent, Thorpe.
Obtained funding: Connolly, Roberts, Gent, Hohnloser.
Administrative, technical, or material support: Connolly, Dorian, Roberts, Gent, Fain, Champagne, Talajic, Coutu, Gronefeld, Hohnloser.
Study supervision: Connolly, Dorian, Roberts, Gent, Talajic.
Financial Disclosures: Drs Connolly, Dorian, and Hohnloser have received research grants from St Jude Medical. As a St Jude Medical employee, Dr Fain is a stockholder in the company. None of the other authors reported disclosures.
Funding/Support: This study was funded by St Jude Medical, Sylmar, Calif.
Role of the Sponsor: St Jude Medical contributed in part to the design of the study but was not involved in data collection, management, analysis, or interpretation. The sponsor reviewed the manuscript before submission and made suggestions.
OPTIC Investigators: Stefan H. Hohnloser, MD, Dietrich Kalusche, MD, Berndt Lüderitz, MD, Joerg O. Schwab, MD, U. Klein, MD, Sven Reek, MD, Udo Sechtem, MD, K. Seidl, MD, A. Schuchert, MD, Jürgen Tebbenjohanns, MD, J. Brachmann, MD, Thomas Kleemann, MD, Torsten Becker, MD, Klaus Dönges, MD, Laurence D. Sterns, MD, Andrew D. Krahn, MD, Douglas Cameron, MD, Paul Dorian, MD, Iqwal Mangat, MD, Victoria Korley, MD, Stuart J. Connolly, MD, Anthony S. L. Tang, MD, Benoit Coutu, MD, Jean Champagne, MD, Tom Hadjis, MD, Magdy Basta, MD, Teresa K. Kus, MD, Richard A. Leather, MD, Mario Talajic, MD, Bernard Thibault, MD, Marc Dubuc, MD, Pierre Gagné, MD, Laurent Macle, MD, Denis Roy, MD, Francois Philippon, MD, Gilles O’Hara, MD, Marcel Gilbert, MD, Franck Molin, MD, Louis Blier, MD, Martin J. Gardner, MD, Werner Klein, MD, Ole Kongstad, MD, Grahame Keith Goode, MD, Paul R. Roberts, MD, Efrain Gonzalez, MD, Steve Bailin, MD, Pratap Reddy, MD, Larry German, MD, Howard Frumin, MD, Niraj Varma, MD, Sheldon Brownstein, MD, William M. Miles, MD, Roger Freedman, MD, David Steinhaus, MD, Jeffrey Goldberger, MD, Carlos Cuello, MD, Thomas A. Mattioni, MD, David W. Riggio, MD, Marwan Bahu, MD, Renzo Cataldo, MD, Vijendra Swarup, MD, and Stephen Shorofsky, MD.