Author Contributions: Drs Schulman and Gerstenblith had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Schulman, Becker, Kass, Terrin, Kelemen, Gerstenblith.
Acquisition of data: Schulman, Becker, Champion, Ernst, Kelemen, Townsend, Capriotti, Gerstenblith.
Analysis and interpretation of data: Schulman, Becker, Champion, Terrin, Forman, Capriotti, Hare, Gerstenblith.
Drafting of the manuscript: Schulman.
Critical revision of the manuscript for important intellectual content: Schulman, Becker, Kass, Champion, Terrin, Forman, Ernst, Kelemen, Townsend, Capriotti, Hare, Gerstenblith.
Statistical analysis: Terrin, Forman.
Obtained funding: Schulman, Kass, Gerstenblith.
Administrative, technical, or material support: Schulman, Kass, Champion, Terrin, Ernst, Kelemen, Townsend, Capriotti, Hare, Gerstenblith.
Study supervision: Schulman, Becker, Terrin.
Financial Disclosures: None reported
Data and Safety Monitoring Committee: Edward K. Kasper, MD (Chair), Edward G. Lakatta, MD, Joel Vertner, PhD, Marie Nolan, DNSc, RN.
Clinical Events Committee: Dale Renlund, MD, Ilan Wittstein, MD, Shawn Robinson, MD.
Data Coordinating Center: Sharon Fick.
Nuclear Cardiology Core Group: Jon Clulow, Terry Frank, Rosalie Cosgriff.
Funding/Support: The study was supported by National Heart, Lung, and Blood Institute grant HL70059.
Role of the Sponsor: The funding agency had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Acknowledgment: We thank the members of the data and safety monitoring committee and the clinical events committee for their commitment to the trial.