Author Contributions: Dr Alexander had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Alexander, Roe, Gibler, Ohman, Peterson.
Acquisition of data: Alexander, Roe, Pollack, Ohman, Peterson.
Analysis and interpretation of data: Alexander, Chen, Roe, Newby, Gibson, Allen-LaPointe, Pollack, Ohman, Peterson.
Drafting of the manuscript: Alexander, Peterson.
Critical revision of the manuscript for important intellectual content: Alexander, Chen, Roe, Newby, Gibson, Allen-LaPointe, Pollack, Gibler, Ohman, Peterson.
Statistical analysis: Alexander, Chen.
Obtained funding: Roe, Pollack, Gibler, Ohman, Peterson.
Administrative, technical, or material support: Alexander, Roe, Allen-LaPointe, Pollack, Gibler, Peterson.
Study supervision: Alexander, Roe, Gibson, Peterson.
Financial Disclosures: Dr Roe received research support and is on the speakers bureau for Millennium Pharmaceuticals, Schering-Plough, and Bristol-Myers Squibb/Sanofi-Aventis. Dr Newby receives research funding from Bristol-Myers Squibb/Sanofi-Aventis and Schering-Plough. Dr Allen-LaPointe receives unrestricted educational grants from Merck and Eli Lilly. Dr Gibler receives grant support from Millennium Pharmaceuticals, Schering-Plough, and Bristol-Myers Squibb/Sanofi-Aventis. Dr Ohman receives research grants from Berlex, Millennium Pharmaceuticals, Bristol-Myers Squibb/Sanofi-Aventis, and Schering-Plough Research Institute. No other authors reported financial disclosures.
Funding/Support: This work is supported in part by grant R01 AG025312-01A1 from the National Institute on Aging (Dr Peterson). CRUSADE is funded by Millennium Pharmaceuticals and Schering-Plough Corporation. Bristol-Myers Squibb/Sanofi-Aventis Pharmaceuticals Partnership provides an unrestricted grant in support of the program.
Role of the Sponsor: Investigators had full, direct access to the data and performed the actual analysis. None of the sponsors played a role in conducting the analysis or in interpreting or reporting the results.
Additional Information: More information on CRUSADE can be found at http://www.crusadeqi.com.
Acknowledgment: We thank the physicians and nurses participating in the CRUSADE Registry and Theresa M. Palabrica, MD, from Millennium Pharmaceuticals, Cambridge, Mass, for her contributions to early concepts and analysis plans.