At the end of 2004, Asia was free from dracunculiasis. The remaining countries where dracunculiasis was endemic, all in Africa, had reported 50% reductions in the number of cases from 2003 to 2004 (from 32,193 to 16,026), and 11 (Benin, Cameroon, Central African Republic, Chad, India, Kenya, Mauritania, Pakistan, Senegal, Uganda, and Yemen) of the original 20 countries with endemic disease had interrupted transmission. Uganda reported zero cases for an entire calendar year for the first time in 2004. Moreover, Benin and Mauritania reported zero indigenous cases for 16 and 13 consecutive months, respectively, as of July 2005. The overall number of villages with endemic disease decreased 33%, from 4,659 in 2003 to 3,109 in 2004 (compared with 23,735 villages in 1993). During January-July 2005, the number of indigenous cases worldwide decreased 31%, from 11,865 to 8,191, compared with the same period for 2004, and the number of cases exported from one country to another decreased 65%, from 69 to 24.