Author Contributions: Dr Morrow had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Morrow, de Lemos, Blazing, Murphy, White, Fox, Califf, Braunwald.
Acquisition of data: de Lemos, Jarolim.
Analysis and interpretation of data: Morrow, de Lemos, Sabatine, Murphy, White, Fox, Califf, Braunwald.
Drafting of the manuscript: Morrow.
Critical revision of the manuscript for important intellectual content: Morrow, de Lemos, Blazing, Sabatine, Murphy, Jarolim, White, Fox, Califf, Braunwald.
Statistical analysis: Morrow, Sabatine, Murphy.
Obtained funding: Morrow, Califf, Braunwald.
Administrative, technical, or material support: de Lemos, Blazing, Jarolim, Califf, Braunwald.
Study supervision: Morrow, de Lemos, Jarolim, Braunwald.
Financial Disclosures: Dr Morrow has received research grant support administered via Brigham and Women’s Hospital from Bayer Healthcare Diagnostics, Beckman Coulter, Biosite, Dade Behring, Merck, and Roche Diagnostics. Dr Morrow has received honoraria for educational presentations from Bayer Healthcare Diagnostics, Beckman Coulter, and Dade Behring. Dr de Lemos has received research grants from Biosite and Roche and honoraria and consulting fees for speaking from Biosite and Roche. Dr Blazing has received honoraria from Merck and Pfizer.
Funding/Support: This study was supported by Merck and Co and Bayer Healthcare Diagnostics Division.
Role of the Sponsor: Staff from Merck assisted in monitoring the progress and conduct of the A to Z trial. Bayer Healthcare provided reagents for B-type natriuretic peptide testing. The sponsors were not involved in the biomarker testing, analysis, or interpretation of the data, or in preparation of the manuscript for this substudy. Medical specialists employed by the sponsors reviewed the manuscript prior to submission.