Author Contributions: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Sweet, Aaltonen, Eng.
Acquisition of data: Sweet, Willis, Gallione, Sawada, Alhopuro, Khoo, Martin, Bridgeman, Heinz, Pilarski, Prior, Frebourg, Teh, Marchuk, Aaltonen, Eng.
Analysis and interpretation of data: Sweet, Zhou, Gallione, Alhopuro, Patocs, Martin, Bridgeman, Lehtonen, Prior, Frebourg, Marchuk, Aaltonen, Eng.
Drafting of the manuscript: Sweet, Willis, Alhopuro, Aaltonen, Eng.
Critical revision of the manuscript for important intellectual content: Sweet, Zhou, Gallione, Sawada, Alhopuro, Khoo, Patocs, Martin, Bridgeman, Heinz, Pilarski, Lehtonen, Prior, Frebourg, Teh, Marchuk, Aaltonen, Eng.
Statistical analysis: Sweet, Eng.
Obtained funding: Aaltonen, Eng.
Administrative, technical, or material support: Willis, Zhou, Alhopuro, Patocs, Martin, Heinz, Pilarski, Lehtonen, Aaltonen, Eng.
Study supervision: Frebourg, Aaltonen, Eng.
Financial Disclosures: None reported.
Funding/Support: This study was partially funded by the American Cancer Society (grant RSG02-151-01-CCE to Dr Eng). Dr Eng is a recipient of the Doris Duke Distinguished Clinical Scientist Award. Dr Aaltonen receives grants from the Academy of Finland (44870, Finnish Center of Excellence Program 2000–2005), Finnish Cancer Society, Sigrid Juselius Foundation, and European Commission (GLG2-CT-2001-01861).
Role of the Sponsors: The funding agencies had no role in design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Acknowledgment: We thank the genetic counselors, physicians, and families who have so kindly contributed to this study; in particular, Barbara Kunz, MS, CGC, and Joy Larsen Haidle, MS, CGC, Hubert Humphrey Institute, Minneapolis, Minn; Katherine Hunt, MS, CGC, University of Texas, San Antonio; John Quillin, MS, CGC, Virginia Commonwealth University, Richmond; Shonee Lesh, MS, CGC, Kaiser Permanente, Sacramento, Calif; Dawn Allain, MS, CGC, Waukesha Memorial Hospital, Waukesha, Wis; and Aimee Fiorito, MS, CGC.