0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
About This Journal |

Additional Information FREE

JAMA. 2005;294(17):E1-E3. doi:10.1001/jama.294.17.E1.
Text Size: A A A
Published online

RANDOMIZED CLINICAL TRIALS STOPPED EARLY FOR EFFICACY (STOP-IT)

The Diabetic Retinopathy Study Research Group.  Preliminary report on effects of photocoagulation therapy.  Am J Ophthalmol. 1976;81:383-396
PubMed
 A randomized trial of propranolol in patients with acute myocardial infarction, I: mortality results.  JAMA. 1982;247:1707-1714
PubMed   |  Link to Article
Kalser MH, Ellenberg SS. Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection.  Arch Surg. 1985;120:899-903
PubMed   |  Link to Article
Fischl MA, Richman DD, Grieco MH.  et al.  The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: a double-blind, placebo-controlled trial.  N Engl J Med. 1987;317:185-191
PubMed   |  Link to Article
CONSENSUS Trial Study Group.  Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).  N Engl J Med. 1987;316:1429-1435
PubMed   |  Link to Article
Cassileth PA, Harrington DP, Hines JD.  et al.  Maintenance chemotherapy prolongs remission duration in adult acute nonlymphocytic leukemia.  J Clin Oncol. 1988;6:583-587
PubMed
Murphy GM, Maurice PD, Norris PG, Morris RW, Hawk JL. Azathioprine treatment in chronic actinic dermatitis: a double-blind controlled trial with monitoring of exposure to ultraviolet radiation.  Br J Dermatol. 1989;121:639-646
PubMed   |  Link to Article
Steering Committee of the Physicians’ Health Study Research Group.  Final report on the aspirin component of the ongoing Physicians’ Health Study.  N Engl J Med. 1989;321:129-135
PubMed   |  Link to Article
French Cooperative Group on Chronic Lymphocytic Leukaemia.  Long-term results of the CHOP regimen in stage C chronic lymphocytic leukaemia.  Br J Haematol. 1989;73:334-340
PubMed   |  Link to Article
Thornes D, Daly L, Lynch G.  et al. Irish Melanoma Group.  Prevention of early recurrence of high risk malignant melanoma by coumarin.  Eur J Surg Oncol. 1989;15:431-435
PubMed
Girard PM, Landman R, Gaudebout C.  et al.  Prevention of Pneumocystis carinii pneumonia relapse by pentamidine aerosol in zidovudine-treated AIDS patients.  Lancet. 1989;1:1348-1353
PubMed   |  Link to Article
Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study.  Lancet. 1989;1:175-179
PubMed   |  Link to Article
Gagnon S, Boota AM, Fischl MA, Baier H, Kirksey OW, La Voie L. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a double-blind, placebo-controlled trial.  N Engl J Med. 1990;323:1444-1450
PubMed   |  Link to Article
Bruzzone M, Repetto L, Chiara S.  et al.  Chemotherapy versus radiotherapy in the management of ovarian cancer patients with pathological complete response or minimal residual disease at second look.  Gynecol Oncol. 1990;38:392-395
PubMed   |  Link to Article
Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators.  The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation.  N Engl J Med. 1990;323:1505-1511
PubMed   |  Link to Article
 Stroke Prevention in Atrial Fibrillation Study: final results.  Circulation. 1991;84:527-539
PubMed   |  Link to Article
Einhaupl KM, Villringer A, Meister W.  et al.  Heparin treatment in sinus venous thrombosis.  Lancet. 1991;338:597-600
PubMed   |  Link to Article
North American Symptomatic Carotid Endarterectomy Trial Collaborators (NASCET).  Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis.  N Engl J Med. 1991;325:445-453
PubMed   |  Link to Article
Ezekowitz MD, Bridgers SL, James KE.  et al. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators.  Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation.  N Engl J Med. 1992;327:1406-1412
PubMed   |  Link to Article
Herskovic A, Martz K, al-Sarraf M.  et al.  Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.  N Engl J Med. 1992;326:1593-1598
PubMed   |  Link to Article
Fenaux P, Le Deley MC, Castaigne S.  et al. European APL 91 Group.  Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia: results of a multicenter randomized trial.  Blood. 1993;82:3241-3249
PubMed
Cooper DA, Gatell JM, Kroon S.  et al.  Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter.  N Engl J Med. 1993;329:297-303
PubMed   |  Link to Article
Giardiello FM, Hamilton SR, Krush AJ.  et al.  Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis.  N Engl J Med. 1993;328:1313-1316
PubMed   |  Link to Article
Parkinson Study Group.  Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease.  N Engl J Med. 1993;328:176-183
PubMed   |  Link to Article
Diabetes Control and Complications Trial Research Group.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.  N Engl J Med. 1993;329:977-986
PubMed   |  Link to Article
Roth JA, Fossella F, Komaki R.  et al.  A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.  J Natl Cancer Inst. 1994;86:673-680
PubMed   |  Link to Article
Connor EM, Sperling RS, Gelber R.  et al.  Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment.  N Engl J Med. 1994;331:1173-1180
PubMed   |  Link to Article
Doval HC, Nul DR, Grancelli HO, Perrone SV, Bortman GR, Curiel R. Randomized trial of low dose amiodarone in severe congestive heart failure.  Lancet. 1994;344:493-498
PubMed   |  Link to Article
Hueston WJ. Albuterol delivered by metered-dose inhaler to treat acute bronchitis.  J Fam Pract. 1994;39:437-440
PubMed
Pepine CJ, Cohn PF, Deedwania PC.  et al.  Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life: the Atenolol Silent Ischemia Study (ASIST).  Circulation. 1994;90:762-768
PubMed   |  Link to Article
Rosell R, Gomez-Codina J, Camps C.  et al.  A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.  N Engl J Med. 1994;330:153-158
PubMed   |  Link to Article
Charache S, Terrin ML, Moore RD.  et al. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.  Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia.  N Engl J Med. 1995;332:1317-1322
PubMed   |  Link to Article
Packer M, Bristow MR, Cohn JN.  et al. US Carvedilol Heart Failure Study Group.  The effect of carvedilol on morbidity and mortality in patients with chronic heart failure.  N Engl J Med. 1996;334:1349-1355
PubMed   |  Link to Article
Clark LC, Combs GF Jr, Turnbull BW.  et al. Nutritional Prevention of Cancer Study Group.  Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial.  JAMA. 1996;276:1957-1963
PubMed   |  Link to Article
UK Collaborative ECMO Trail Group.  UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation.  Lancet. 1996;348:75-82
PubMed   |  Link to Article
Delta Coordinating Committee.  Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals.  Lancet. 1996;348:283-291
PubMed   |  Link to Article
Spector SA, McKinley GF, Lalezari JP.  et al.  Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS.  N Engl J Med. 1996;334:1491-1497
PubMed   |  Link to Article
Marques da Costa R, Jesus FM, Aniceto C, Mendes M. Double-blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers.  Am J Surg. 1997;173:165-168
PubMed   |  Link to Article
Hammer SM, Squires KE, Hughes MD.  et al. AIDS Clinical Trials Group 320 Study Team.  A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less.  N Engl J Med. 1997;337:725-733
PubMed   |  Link to Article
Englund JA, Baker CJ, Raskino C.  et al. AIDS Clinical Trials Group (ACTG) Study 152 Team.  Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected children.  N Engl J Med. 1997;336:1704-1712
PubMed   |  Link to Article
Staessen JA, Fagard R, Thijs L.  et al. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.  Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension.  Lancet. 1997;350:757-764
PubMed   |  Link to Article
 Randomised placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE study.  Lancet. 1997;349:1429-1435
PubMed   |  Link to Article
 Randomised trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial.  Lancet. 1997;349:1413-1421
PubMed   |  Link to Article
Group GISEN (Gruppo Italiano di Studi Epidemiologici in Nefrologia).  Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy.  Lancet. 1996;349:1857-1863
PubMed
Jacobson JM, Greenspan JS, Spritzler J.  et al.  Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection.  N Engl J Med. 1997;336:1487-1493
PubMed   |  Link to Article
EPILOG Investigators.  Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization.  N Engl J Med. 1997;336:1689-1697
PubMed   |  Link to Article
Neonatal Inhaled Nitric Oxide Study Group.  Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure.  N Engl J Med. 1997;336:597-604
PubMed   |  Link to Article
Studies of Ocular Complications of AIDS Research Group/AIDS Clinical Trials Group.  HPMPC: parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial—a randomized, controlled trial.  Ann Intern Med. 1997;126:264-274
PubMed   |  Link to Article
Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators.  A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias.  N Engl J Med. 1997;337:1576-1583
PubMed   |  Link to Article
Fisher B, Costantino JP, Wickerham DL.  et al.  Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.  J Natl Cancer Inst. 1998;90:1371-1388
PubMed   |  Link to Article
European Study Group on Interferon Beta-1b in Secondary Progressive MS.  Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis.  Lancet. 1998;352:1491-1497
PubMed   |  Link to Article
Aigner KR, Gailhofer S, Kopp S. Regional versus systemic chemotherapy for advanced pancreatic cancer: a randomized study.  Hepatogastroenterology. 1998;45:1125-1129
PubMed
Adams RJ, McKie VC, Hsu L.  et al.  Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.  N Engl J Med. 1998;339:5-11
PubMed   |  Link to Article
Svensson LG, Hess KR, D’Agostino RS.  et al.  Reduction of neurologic injury after high-risk thoracoabdominal aortic operation.  Ann Thorac Surg. 1998;66:132-138
PubMed   |  Link to Article
Amato MB, Barbas CS, Medeiros DM.  et al.  Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.  N Engl J Med. 1998;338:347-354
PubMed   |  Link to Article
Downs JR, Clearfield M, Weis S.  et al.  Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS.  JAMA. 1998;279:1615-1622
PubMed   |  Link to Article
Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group.  Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.  N Engl J Med. 1998;339:1349-1357
PubMed   |  Link to Article
 The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial.  Lancet. 1999;353:9-13
PubMed   |  Link to Article
 Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF).  Lancet. 1999;353:2001-2007
PubMed   |  Link to Article
Gupta A, Naik A, Vora A, Lokhandwala Y. Comparison of efficacy of intravenous diltiazem and esmolol in terminating supraventricular tachycardia.  J Assoc Physicians India. 1999;47:969-972
PubMed
Kearon C, Gent M, Hirsh J.  et al.  A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.  N Engl J Med. 1999;340:901-907
PubMed   |  Link to Article
Lau WY, Leung TW, Ho SK.  et al.  Adjuvant intra-arterial iodine-131-labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial.  Lancet. 1999;353:797-801
PubMed   |  Link to Article
Medical Research Council Renal Cancer Collaborators.  Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial.  Lancet. 1999;353:14-17
PubMed   |  Link to Article
Connolly SJ, Sheldon R, Roberts RS, Gent M. The North American Vasovagal Pacemaker Study (VPS): a randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope.  J Am Coll Cardiol. 1999;33:16-20
PubMed   |  Link to Article
Felson DT, LaValley MP, Baldassare AR.  et al.  The Prosorba column for treatment of refractory rheumatoid arthritis: a randomized, double-blind, sham-controlled trial.  Arthritis Rheum. 1999;42:2153-2159
PubMed   |  Link to Article
Pitt B, Zannad F, Remme WJ.  et al. Randomized Aldactone Evaluation Study Investigators.  The effect of spironolactone on morbidity and mortality in patients with severe heart failure.  N Engl J Med. 1999;341:709-717
PubMed   |  Link to Article
Poldermans D, Boersma E, Bax JJ.  et al. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group.  The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery.  N Engl J Med. 1999;341:1789-1794
PubMed   |  Link to Article
Cooper JS, Guo MD, Herskovic A.  et al. Radiation Therapy Oncology Group.  Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01).  JAMA. 1999;281:1623-1627
PubMed   |  Link to Article
Dabis F, Msellati P, Meda N.  et al.  6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d’Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial.  Lancet. 1999;353:786-792
PubMed   |  Link to Article
Premawardhena AP, de Silva CE, Fonseka MMD, Gunatilake SB, de Silva HJ. Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised, placebo controlled trial.  BMJ. 1999;318:1041-1043
PubMed   |  Link to Article
Anglaret X, Chene G, Attia A.  et al. Cotrimo-CI Study Group.  Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1 infected adults in Abidjan, Cote d’Ivoire: a randomized trial.  Lancet. 1999;353:1463-1468
PubMed   |  Link to Article
Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomized trial.  Lancet. 1999;354:1851-1858
PubMed   |  Link to Article
Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G.Heart Outcomes Prevention Evaluation Study Investigators.  Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.  N Engl J Med. 2000;342:145-153
PubMed   |  Link to Article
Esprit Investigators.  Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial.  Lancet. 2000;356:2037-2044
PubMed   |  Link to Article
Ainsworth SB, Beresford MW, Milligan DW.  et al.  Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25-29 weeks’ gestation: a randomised trial.  Lancet. 2000;355:1387-1392
PubMed   |  Link to Article
Comella P, Frasci G, Panza N.  et al.  Randomized trial comparing cisplatin, gemcitabine, and vinorelbine with either cisplatin and gemcitabine or cisplatin and vinorelbine in advanced non-small-cell lung cancer: interim analysis of a phase III trial of the Southern Italy Cooperative Oncology Group.  J Clin Oncol. 2000;18:1451-1457
PubMed
Acute Respiratory Distress Syndrome Network.  Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.  N Engl J Med. 2000;342:1301-1308
PubMed   |  Link to Article
Bergamasco B, Frattola L, Muratorio A, Piccoli F, Mailland F, Parnetti L. Alpha-dihydroergocryptine in the treatment of de novo parkinsonian patients: results of a multicentre, randomized, double-blind, placebo-controlled study.  Acta Neurol Scand. 2000;101:372-380
PubMed   |  Link to Article
Jacobs LD, Beck RW, Simon JH.  et al.  Intramuscular interferon beta-1A therapy initiated during a first demyelinating event in multiple sclerosis.  N Engl J Med. 2000;343:898-904
PubMed   |  Link to Article
Sturm B, Pacher R, Strametz-Juranek J, Berger R, Frey B, Stanek B. Effect of beta 1 blockade with atenolol on progression of heart failure in patients pretreated with high-dose enalapril.  Eur J Heart Fail. 2000;2:407-412
PubMed   |  Link to Article
Packer M, Coats AJ, Fowler MB.  et al.  Effect of carvedilol on survival in severe chronic heart failure.  N Engl J Med. 2001;344:1651-1658
PubMed   |  Link to Article
Kalb R, Trautmann-Sponsel RD, Kieser M. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients: a randomized double-blind multicenter clinical trial.  Pharmacopsychiatry. 2001;34:96-103
PubMed   |  Link to Article
Holmes M, Stewart J, Rice M. Flexible cystoscopy: is the volume and content of the urethral gel critical?  J Endourol. 2001;15:855-858
PubMed   |  Link to Article
Ross AM, Gao R, Coyne KS.  et al.  A randomized trial confirming the efficacy of reduced dose recombinant tissue plasminogen activator in a Chinese myocardial infarction population and demonstrating superiority to usual dose urokinase: the TUCC trial.  Am Heart J. 2001;142:244-247
PubMed   |  Link to Article
Agodoa LY, Appel L, Bakris GL.  et al. African American Study of Kidney Disease and Hypertension (AASK) Study Group.  Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.  JAMA. 2001;285:2719-2728
PubMed   |  Link to Article
Bernard GR, Vincent J-L, Laterre P-F.  et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis.  N Engl J Med. 2001;344:699-709
PubMed   |  Link to Article
Chan FK, Chung SCS, Suen BY.  et al.  Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.  N Engl J Med. 2001;344:967-973
PubMed   |  Link to Article
Frasci G, Lorusso V, Panza N.  et al.  Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer: a Southern Italy Cooperative Oncology Group (SICOG) phase III trial.  Lung Cancer. 2001;34:(suppl 4)  S65-S69
PubMed   |  Link to Article
Toner GC, Stockler MR, Boyer MJ.  et al.  Comparison of two standard chemotherapy regimens for good-prognosis germ-cell tumours: a randomised trial.  Lancet. 2001;357:739-745
PubMed   |  Link to Article
Van den Berghe G, Wouters P, Weekers F.  et al.  Intensive insulin therapy in critically ill patients.  N Engl J Med. 2001;345:1359-1367
PubMed   |  Link to Article
Ammirati F, Colivvichi F, Santini M.Syncope Diagnosis and Treatment Study Investigators.  Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope: a multicenter, randomized, controlled trial.  Circulation. 2001;104:52-57
PubMed   |  Link to Article
Lauer SJ, Shuster JJ, Mahoney DH Jr.  et al.  A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial.  Leukemia. 2001;15:1038-1045
PubMed   |  Link to Article
Press OW, LeBlanc M, Lichter AS.  et al.  Phase III randomized intergroup trial of subtotal lymphoid irradiation versus doxorubicin, vinblastine, and subtotal lymphoid irradiation for stage IA to IIA Hodgkin’s disease.  J Clin Oncol. 2001;19:4238-4244
PubMed
Rovensky J, Micekova D, Gubzova Z.  et al.  Treatment of knee osteoarthritis with a topical non-steroidal antiinflammatory drug: results of a randomized, double-blind, placebo-controlled study on the efficacy and safety of a 5% ibuprofen cream.  Drugs Exp Clin Res. 2001;27:209-221
PubMed
Noda K, Nishiwaki Y, Kawahara M.  et al.  Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer.  N Engl J Med. 2002;346:85-91
PubMed   |  Link to Article
Moss AJ, Zareba W, Hall WJ.  et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.  N Engl J Med. 2002;346:877-883
PubMed   |  Link to Article
Tsuyuki RT, Johnson JA, Teo KK.  et al.  A randomized trial of the effect of community pharmacist intervention on cholesterol risk management: the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP).  Arch Intern Med. 2002;162:1149-1155
PubMed   |  Link to Article
Bernard P, Chosidow O, Vaillant L. Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial.  BMJ. 2002;325:864
PubMed   |  Link to Article
Gibson RL, Emerson J, McNamara S.  et al.  Significant microbiologic effect of inhaled tobramycin in young children with cystic fibrosis.  Am J Respir Crit Care Med. 2003;167:841-849
PubMed   |  Link to Article
Heemann U, Treichel U, Loock J.  et al.  Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study.  Hepatology. 2002;36:949-958
PubMed
Knowler WC, Barrett-Connor E, Fowler SE.  et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.  N Engl J Med. 2002;346:393-403
PubMed   |  Link to Article
Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W.Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators.  Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism.  N Engl J Med. 2002;347:1143-1150
PubMed   |  Link to Article
Lai KC, Lam SK, Chu KM.  et al.  Lansoprazole for the Prevention of Recurrences of Ulcer Complications from Long-Term Low-Dose Aspirin Use.  N Engl J Med. 2002;346:2033-2038
PubMed   |  Link to Article
Molyneux A. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial.  Lancet. 2002;360:1267-1274
PubMed   |  Link to Article
Moon JC, Kalra PR, Coats AJS. DANAMI-2: is primary angioplasty superior to thrombolysis in acute MI when the patient has to be transferred to an invasive centre?  Int J Cardiol. 2002;85:199-201
PubMed   |  Link to Article
Prandoni P, Bruchi O, Sabbion P.  et al.  Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study.  Arch Intern Med. 2002;162:1966-1971
PubMed   |  Link to Article
Weaver LK, Hopkins RO, Chan KJ.  et al.  Hyperbaric oxygen for acute carbon monoxide poisoning.  N Engl J Med. 2002;347:1057-1067
PubMed   |  Link to Article
Colhoun HM, Betteridge DJ, Durrington PN.  et al. CARDS Investigators.  Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.  Lancet. 2004;364:685-696
PubMed   |  Link to Article
Molina JM, Tourneur M, Sarfati C.  et al. Agence Nationale de Recherches sur le 090 Study Group.  Fumagillin treatment of intestinal microsporidiosis.  N Engl J Med. 2002;346:1963-1969
PubMed   |  Link to Article
Jones KL, Arslanian S, Peterokova VA, Park JS, Thomlinson MJ. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial.  Diabetes Care. 2002;25:89-94
PubMed   |  Link to Article
Chen-Mok M, Bangdiwala SI, Dominik R, Hays M, Irsula B, Sokal DC. Termination of a randomized controlled trial of two vasectomy techniques.  Control Clin Trials. 2003;24:78-84
PubMed   |  Link to Article
Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial.  Lancet. 2003;361:117-124
PubMed   |  Link to Article
Ferrer M, Esquinas A, Arancibia F.  et al.  Noninvasive ventilation during persistent weaning failure: a randomized controlled trial.  Am J Respir Crit Care Med. 2003;168:70-76
PubMed   |  Link to Article
Fudala PJ, Bridge TP, Herbert S.  et al. Buprenorphine/Naloxone Collaborative Study Group.  Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone.  N Engl J Med. 2003;349:949-958
PubMed   |  Link to Article
Goss PE, Ingle JN, Martino S.  et al.  A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.  N Engl J Med. 2003;349:1793-1802
PubMed   |  Link to Article
Higgins B, Thompson IM. The prostate cancer prevention trial: current status.  J Urol. 2004;171:S15-S17
PubMed   |  Link to Article
AFFIRM First Antiarrhythmic Drug Substudy Investigators.  Maintenance of sinus rhythm in patients with atrial fibrillation: an AFFIRM substudy of the first antiarrhythmic drug.  J Am Coll Cardiol. 2003;42:20-29
PubMed   |  Link to Article
Moore MJ, Hamm J, Dancey J.  et al. National Cancer Institute of Canada Clinical Trials Group.  Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.  J Clin Oncol. 2003;21:3296-3302
PubMed   |  Link to Article
Nademanee K, Veerakul G, Mower M.  et al.  Defibrillator versus beta-Blockers for Unexplained Death in Thailand (DEBUT): a randomized clinical trial.  Circulation. 2003;107:2221-2226
PubMed   |  Link to Article
Ortner ME, Caca K, Berr F.  et al.  Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study.  Gastroenterology. 2003;125:1355-1363
PubMed   |  Link to Article
Ridker PM, Goldhaber SZ, Danielson E.  et al. PREVENT Investigators.  Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism.  N Engl J Med. 2003;348:1425-1434
PubMed   |  Link to Article
Sandler RS, Halabi S, Baron JA.  et al.  A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer [published correction appears in N Engl J Med. 2003;348:1939].  N Engl J Med. 2003;348:883-890
PubMed   |  Link to Article
Schrader J, Luders S, Kulschewski A.  et al. Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group.  The ACCESS study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors.  Stroke. 2003;34:1699-1703
PubMed   |  Link to Article
Van Heek NT, De Castro SM, van Eijck CH.  et al.  The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer: a prospective randomized multicenter trial with special focus on assessment of quality of life.  Ann Surg. 2003;238:894-902
PubMed   |  Link to Article
Yang JC, Haworth L, Sherry RM.  et al.  A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.  N Engl J Med. 2003;349:427-434
PubMed   |  Link to Article
Cook TM, Porter MV. Randomized comparison of the classic Laryngeal Mask Airway with the Airway Management Device during anesthesia.  Br J Anaesth. 2003;91:672-677
PubMed   |  Link to Article
Mori K, Kondo T, Kamiyama Y, Kano Y, Tominaga K. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer.  Cancer Chemother Pharmacol. 2003;51:403-406
PubMed
Sever PS, Dahlof B, Poulter NR.  et al. ASCOT Investigators.  Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower than average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomized controlled trial.  Lancet. 2003;361:1149-1158
PubMed   |  Link to Article
Jacobs S, Price Evans DA, Tariq M, Al Omar NF. Fluconazole improves survival in septic shock: a randomized double blind prospective study.  Crit Care Med. 2003;31:1938-1946
PubMed   |  Link to Article
Matsumori A.Assessment of Response to Candesartan in Heart Failure in Japan (ARCH-J) Study Investigators.  Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure.  Eur J Heart Fail. 2003;5:669-677
PubMed   |  Link to Article
Markman M, Liu PY, Wilczynski S.  et al. Southwest Oncology Group/Gynecologic Oncology Group.  Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial.  J Clin Oncol. 2003;21:2460-2465
PubMed   |  Link to Article
O’Brien SG, Guilhot F, Larson RA.  et al. IRIS Investigators.  Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.  N Engl J Med. 2003;348:994-1004
PubMed   |  Link to Article
Chang AK, Schoeman G, Hill M. A randomized clinical trial to assess the efficacy of the Epley maneuver in the treatment of acute benign positional vertigo.  Acad Emerg Med. 2004;11:918-924
PubMed   |  Link to Article
Liaw YF, Sung JJ, Chow WC.  et al. Cirrhosis Asian Lamivudine Multicentre Study Group.  Lamivudine for patients with chronic hepatitis B and advanced liver disease.  N Engl J Med. 2004;351:1521-1531
PubMed   |  Link to Article
Saag MS, Cahn P, Raffi F.  et al. FTC-301A Study Team.  Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: a randomized trial.  JAMA. 2004;292:180-189
PubMed   |  Link to Article
Senat MV, Deprest J, Boulvain M, Paupe A, Winer N, Ville Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome.  N Engl J Med. 2004;351:136-144
PubMed   |  Link to Article
Trnavsky K, Fischer M, Vogtle-Junkert U, Schreyger F. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.  J Rheumatol. 2004;31:565-572
PubMed
Tsui MH, Ngan Kee WD, Ng FF, Lau TK. A double blinded randomised placebo-controlled study of intramuscular pethidine for pain relief in the first stage of labour.  BJOG. 2004;111:648-655
PubMed   |  Link to Article
Chintu C, Bhat GJ, Walker AS.  et al. CHAP Trial Team.  Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial.  Lancet. 2004;364:1865-1871
PubMed   |  Link to Article
Lallemant M, Jourdain G, Le Coeur S.  et al. Perinatal HIV Prevention Trial (Thailand) Investigators.  Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand.  N Engl J Med. 2004;351:217-228
PubMed   |  Link to Article
Suwelack B, Gerhardt U, Hohage H. Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy.  Am J Transplant. 2004;4:655-662
PubMed   |  Link to Article
Merten GJ, Burgess WP, Gray LV.  et al.  Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.  JAMA. 2004;291:2328-2334
PubMed   |  Link to Article
Taylor AL, Ziesche S, Yancy C.  et al. African-American Heart Failure Trial Investigators.  Combination of isosorbide dinitrate and hydralazine in blacks with heart failure [published correction appears in N Engl J Med. 2005;352:1276].  N Engl J Med. 2004;351:2049-2057
PubMed   |  Link to Article

Figures

Tables

References

The Diabetic Retinopathy Study Research Group.  Preliminary report on effects of photocoagulation therapy.  Am J Ophthalmol. 1976;81:383-396
PubMed
 A randomized trial of propranolol in patients with acute myocardial infarction, I: mortality results.  JAMA. 1982;247:1707-1714
PubMed   |  Link to Article
Kalser MH, Ellenberg SS. Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection.  Arch Surg. 1985;120:899-903
PubMed   |  Link to Article
Fischl MA, Richman DD, Grieco MH.  et al.  The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: a double-blind, placebo-controlled trial.  N Engl J Med. 1987;317:185-191
PubMed   |  Link to Article
CONSENSUS Trial Study Group.  Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).  N Engl J Med. 1987;316:1429-1435
PubMed   |  Link to Article
Cassileth PA, Harrington DP, Hines JD.  et al.  Maintenance chemotherapy prolongs remission duration in adult acute nonlymphocytic leukemia.  J Clin Oncol. 1988;6:583-587
PubMed
Murphy GM, Maurice PD, Norris PG, Morris RW, Hawk JL. Azathioprine treatment in chronic actinic dermatitis: a double-blind controlled trial with monitoring of exposure to ultraviolet radiation.  Br J Dermatol. 1989;121:639-646
PubMed   |  Link to Article
Steering Committee of the Physicians’ Health Study Research Group.  Final report on the aspirin component of the ongoing Physicians’ Health Study.  N Engl J Med. 1989;321:129-135
PubMed   |  Link to Article
French Cooperative Group on Chronic Lymphocytic Leukaemia.  Long-term results of the CHOP regimen in stage C chronic lymphocytic leukaemia.  Br J Haematol. 1989;73:334-340
PubMed   |  Link to Article
Thornes D, Daly L, Lynch G.  et al. Irish Melanoma Group.  Prevention of early recurrence of high risk malignant melanoma by coumarin.  Eur J Surg Oncol. 1989;15:431-435
PubMed
Girard PM, Landman R, Gaudebout C.  et al.  Prevention of Pneumocystis carinii pneumonia relapse by pentamidine aerosol in zidovudine-treated AIDS patients.  Lancet. 1989;1:1348-1353
PubMed   |  Link to Article
Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study.  Lancet. 1989;1:175-179
PubMed   |  Link to Article
Gagnon S, Boota AM, Fischl MA, Baier H, Kirksey OW, La Voie L. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a double-blind, placebo-controlled trial.  N Engl J Med. 1990;323:1444-1450
PubMed   |  Link to Article
Bruzzone M, Repetto L, Chiara S.  et al.  Chemotherapy versus radiotherapy in the management of ovarian cancer patients with pathological complete response or minimal residual disease at second look.  Gynecol Oncol. 1990;38:392-395
PubMed   |  Link to Article
Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators.  The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation.  N Engl J Med. 1990;323:1505-1511
PubMed   |  Link to Article
 Stroke Prevention in Atrial Fibrillation Study: final results.  Circulation. 1991;84:527-539
PubMed   |  Link to Article
Einhaupl KM, Villringer A, Meister W.  et al.  Heparin treatment in sinus venous thrombosis.  Lancet. 1991;338:597-600
PubMed   |  Link to Article
North American Symptomatic Carotid Endarterectomy Trial Collaborators (NASCET).  Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis.  N Engl J Med. 1991;325:445-453
PubMed   |  Link to Article
Ezekowitz MD, Bridgers SL, James KE.  et al. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators.  Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation.  N Engl J Med. 1992;327:1406-1412
PubMed   |  Link to Article
Herskovic A, Martz K, al-Sarraf M.  et al.  Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.  N Engl J Med. 1992;326:1593-1598
PubMed   |  Link to Article
Fenaux P, Le Deley MC, Castaigne S.  et al. European APL 91 Group.  Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia: results of a multicenter randomized trial.  Blood. 1993;82:3241-3249
PubMed
Cooper DA, Gatell JM, Kroon S.  et al.  Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter.  N Engl J Med. 1993;329:297-303
PubMed   |  Link to Article
Giardiello FM, Hamilton SR, Krush AJ.  et al.  Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis.  N Engl J Med. 1993;328:1313-1316
PubMed   |  Link to Article
Parkinson Study Group.  Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease.  N Engl J Med. 1993;328:176-183
PubMed   |  Link to Article
Diabetes Control and Complications Trial Research Group.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.  N Engl J Med. 1993;329:977-986
PubMed   |  Link to Article
Roth JA, Fossella F, Komaki R.  et al.  A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.  J Natl Cancer Inst. 1994;86:673-680
PubMed   |  Link to Article
Connor EM, Sperling RS, Gelber R.  et al.  Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment.  N Engl J Med. 1994;331:1173-1180
PubMed   |  Link to Article
Doval HC, Nul DR, Grancelli HO, Perrone SV, Bortman GR, Curiel R. Randomized trial of low dose amiodarone in severe congestive heart failure.  Lancet. 1994;344:493-498
PubMed   |  Link to Article
Hueston WJ. Albuterol delivered by metered-dose inhaler to treat acute bronchitis.  J Fam Pract. 1994;39:437-440
PubMed
Pepine CJ, Cohn PF, Deedwania PC.  et al.  Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life: the Atenolol Silent Ischemia Study (ASIST).  Circulation. 1994;90:762-768
PubMed   |  Link to Article
Rosell R, Gomez-Codina J, Camps C.  et al.  A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.  N Engl J Med. 1994;330:153-158
PubMed   |  Link to Article
Charache S, Terrin ML, Moore RD.  et al. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.  Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia.  N Engl J Med. 1995;332:1317-1322
PubMed   |  Link to Article
Packer M, Bristow MR, Cohn JN.  et al. US Carvedilol Heart Failure Study Group.  The effect of carvedilol on morbidity and mortality in patients with chronic heart failure.  N Engl J Med. 1996;334:1349-1355
PubMed   |  Link to Article
Clark LC, Combs GF Jr, Turnbull BW.  et al. Nutritional Prevention of Cancer Study Group.  Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial.  JAMA. 1996;276:1957-1963
PubMed   |  Link to Article
UK Collaborative ECMO Trail Group.  UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation.  Lancet. 1996;348:75-82
PubMed   |  Link to Article
Delta Coordinating Committee.  Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals.  Lancet. 1996;348:283-291
PubMed   |  Link to Article
Spector SA, McKinley GF, Lalezari JP.  et al.  Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS.  N Engl J Med. 1996;334:1491-1497
PubMed   |  Link to Article
Marques da Costa R, Jesus FM, Aniceto C, Mendes M. Double-blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers.  Am J Surg. 1997;173:165-168
PubMed   |  Link to Article
Hammer SM, Squires KE, Hughes MD.  et al. AIDS Clinical Trials Group 320 Study Team.  A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less.  N Engl J Med. 1997;337:725-733
PubMed   |  Link to Article
Englund JA, Baker CJ, Raskino C.  et al. AIDS Clinical Trials Group (ACTG) Study 152 Team.  Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected children.  N Engl J Med. 1997;336:1704-1712
PubMed   |  Link to Article
Staessen JA, Fagard R, Thijs L.  et al. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.  Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension.  Lancet. 1997;350:757-764
PubMed   |  Link to Article
 Randomised placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE study.  Lancet. 1997;349:1429-1435
PubMed   |  Link to Article
 Randomised trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial.  Lancet. 1997;349:1413-1421
PubMed   |  Link to Article
Group GISEN (Gruppo Italiano di Studi Epidemiologici in Nefrologia).  Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy.  Lancet. 1996;349:1857-1863
PubMed
Jacobson JM, Greenspan JS, Spritzler J.  et al.  Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection.  N Engl J Med. 1997;336:1487-1493
PubMed   |  Link to Article
EPILOG Investigators.  Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization.  N Engl J Med. 1997;336:1689-1697
PubMed   |  Link to Article
Neonatal Inhaled Nitric Oxide Study Group.  Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure.  N Engl J Med. 1997;336:597-604
PubMed   |  Link to Article
Studies of Ocular Complications of AIDS Research Group/AIDS Clinical Trials Group.  HPMPC: parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial—a randomized, controlled trial.  Ann Intern Med. 1997;126:264-274
PubMed   |  Link to Article
Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators.  A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias.  N Engl J Med. 1997;337:1576-1583
PubMed   |  Link to Article
Fisher B, Costantino JP, Wickerham DL.  et al.  Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.  J Natl Cancer Inst. 1998;90:1371-1388
PubMed   |  Link to Article
European Study Group on Interferon Beta-1b in Secondary Progressive MS.  Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis.  Lancet. 1998;352:1491-1497
PubMed   |  Link to Article
Aigner KR, Gailhofer S, Kopp S. Regional versus systemic chemotherapy for advanced pancreatic cancer: a randomized study.  Hepatogastroenterology. 1998;45:1125-1129
PubMed
Adams RJ, McKie VC, Hsu L.  et al.  Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.  N Engl J Med. 1998;339:5-11
PubMed   |  Link to Article
Svensson LG, Hess KR, D’Agostino RS.  et al.  Reduction of neurologic injury after high-risk thoracoabdominal aortic operation.  Ann Thorac Surg. 1998;66:132-138
PubMed   |  Link to Article
Amato MB, Barbas CS, Medeiros DM.  et al.  Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.  N Engl J Med. 1998;338:347-354
PubMed   |  Link to Article
Downs JR, Clearfield M, Weis S.  et al.  Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS.  JAMA. 1998;279:1615-1622
PubMed   |  Link to Article
Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group.  Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.  N Engl J Med. 1998;339:1349-1357
PubMed   |  Link to Article
 The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial.  Lancet. 1999;353:9-13
PubMed   |  Link to Article
 Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF).  Lancet. 1999;353:2001-2007
PubMed   |  Link to Article
Gupta A, Naik A, Vora A, Lokhandwala Y. Comparison of efficacy of intravenous diltiazem and esmolol in terminating supraventricular tachycardia.  J Assoc Physicians India. 1999;47:969-972
PubMed
Kearon C, Gent M, Hirsh J.  et al.  A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.  N Engl J Med. 1999;340:901-907
PubMed   |  Link to Article
Lau WY, Leung TW, Ho SK.  et al.  Adjuvant intra-arterial iodine-131-labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial.  Lancet. 1999;353:797-801
PubMed   |  Link to Article
Medical Research Council Renal Cancer Collaborators.  Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial.  Lancet. 1999;353:14-17
PubMed   |  Link to Article
Connolly SJ, Sheldon R, Roberts RS, Gent M. The North American Vasovagal Pacemaker Study (VPS): a randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope.  J Am Coll Cardiol. 1999;33:16-20
PubMed   |  Link to Article
Felson DT, LaValley MP, Baldassare AR.  et al.  The Prosorba column for treatment of refractory rheumatoid arthritis: a randomized, double-blind, sham-controlled trial.  Arthritis Rheum. 1999;42:2153-2159
PubMed   |  Link to Article
Pitt B, Zannad F, Remme WJ.  et al. Randomized Aldactone Evaluation Study Investigators.  The effect of spironolactone on morbidity and mortality in patients with severe heart failure.  N Engl J Med. 1999;341:709-717
PubMed   |  Link to Article
Poldermans D, Boersma E, Bax JJ.  et al. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group.  The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery.  N Engl J Med. 1999;341:1789-1794
PubMed   |  Link to Article
Cooper JS, Guo MD, Herskovic A.  et al. Radiation Therapy Oncology Group.  Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01).  JAMA. 1999;281:1623-1627
PubMed   |  Link to Article
Dabis F, Msellati P, Meda N.  et al.  6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d’Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial.  Lancet. 1999;353:786-792
PubMed   |  Link to Article
Premawardhena AP, de Silva CE, Fonseka MMD, Gunatilake SB, de Silva HJ. Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised, placebo controlled trial.  BMJ. 1999;318:1041-1043
PubMed   |  Link to Article
Anglaret X, Chene G, Attia A.  et al. Cotrimo-CI Study Group.  Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1 infected adults in Abidjan, Cote d’Ivoire: a randomized trial.  Lancet. 1999;353:1463-1468
PubMed   |  Link to Article
Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomized trial.  Lancet. 1999;354:1851-1858
PubMed   |  Link to Article
Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G.Heart Outcomes Prevention Evaluation Study Investigators.  Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.  N Engl J Med. 2000;342:145-153
PubMed   |  Link to Article
Esprit Investigators.  Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial.  Lancet. 2000;356:2037-2044
PubMed   |  Link to Article
Ainsworth SB, Beresford MW, Milligan DW.  et al.  Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25-29 weeks’ gestation: a randomised trial.  Lancet. 2000;355:1387-1392
PubMed   |  Link to Article
Comella P, Frasci G, Panza N.  et al.  Randomized trial comparing cisplatin, gemcitabine, and vinorelbine with either cisplatin and gemcitabine or cisplatin and vinorelbine in advanced non-small-cell lung cancer: interim analysis of a phase III trial of the Southern Italy Cooperative Oncology Group.  J Clin Oncol. 2000;18:1451-1457
PubMed
Acute Respiratory Distress Syndrome Network.  Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.  N Engl J Med. 2000;342:1301-1308
PubMed   |  Link to Article
Bergamasco B, Frattola L, Muratorio A, Piccoli F, Mailland F, Parnetti L. Alpha-dihydroergocryptine in the treatment of de novo parkinsonian patients: results of a multicentre, randomized, double-blind, placebo-controlled study.  Acta Neurol Scand. 2000;101:372-380
PubMed   |  Link to Article
Jacobs LD, Beck RW, Simon JH.  et al.  Intramuscular interferon beta-1A therapy initiated during a first demyelinating event in multiple sclerosis.  N Engl J Med. 2000;343:898-904
PubMed   |  Link to Article
Sturm B, Pacher R, Strametz-Juranek J, Berger R, Frey B, Stanek B. Effect of beta 1 blockade with atenolol on progression of heart failure in patients pretreated with high-dose enalapril.  Eur J Heart Fail. 2000;2:407-412
PubMed   |  Link to Article
Packer M, Coats AJ, Fowler MB.  et al.  Effect of carvedilol on survival in severe chronic heart failure.  N Engl J Med. 2001;344:1651-1658
PubMed   |  Link to Article
Kalb R, Trautmann-Sponsel RD, Kieser M. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients: a randomized double-blind multicenter clinical trial.  Pharmacopsychiatry. 2001;34:96-103
PubMed   |  Link to Article
Holmes M, Stewart J, Rice M. Flexible cystoscopy: is the volume and content of the urethral gel critical?  J Endourol. 2001;15:855-858
PubMed   |  Link to Article
Ross AM, Gao R, Coyne KS.  et al.  A randomized trial confirming the efficacy of reduced dose recombinant tissue plasminogen activator in a Chinese myocardial infarction population and demonstrating superiority to usual dose urokinase: the TUCC trial.  Am Heart J. 2001;142:244-247
PubMed   |  Link to Article
Agodoa LY, Appel L, Bakris GL.  et al. African American Study of Kidney Disease and Hypertension (AASK) Study Group.  Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.  JAMA. 2001;285:2719-2728
PubMed   |  Link to Article
Bernard GR, Vincent J-L, Laterre P-F.  et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis.  N Engl J Med. 2001;344:699-709
PubMed   |  Link to Article
Chan FK, Chung SCS, Suen BY.  et al.  Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.  N Engl J Med. 2001;344:967-973
PubMed   |  Link to Article
Frasci G, Lorusso V, Panza N.  et al.  Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer: a Southern Italy Cooperative Oncology Group (SICOG) phase III trial.  Lung Cancer. 2001;34:(suppl 4)  S65-S69
PubMed   |  Link to Article
Toner GC, Stockler MR, Boyer MJ.  et al.  Comparison of two standard chemotherapy regimens for good-prognosis germ-cell tumours: a randomised trial.  Lancet. 2001;357:739-745
PubMed   |  Link to Article
Van den Berghe G, Wouters P, Weekers F.  et al.  Intensive insulin therapy in critically ill patients.  N Engl J Med. 2001;345:1359-1367
PubMed   |  Link to Article
Ammirati F, Colivvichi F, Santini M.Syncope Diagnosis and Treatment Study Investigators.  Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope: a multicenter, randomized, controlled trial.  Circulation. 2001;104:52-57
PubMed   |  Link to Article
Lauer SJ, Shuster JJ, Mahoney DH Jr.  et al.  A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial.  Leukemia. 2001;15:1038-1045
PubMed   |  Link to Article
Press OW, LeBlanc M, Lichter AS.  et al.  Phase III randomized intergroup trial of subtotal lymphoid irradiation versus doxorubicin, vinblastine, and subtotal lymphoid irradiation for stage IA to IIA Hodgkin’s disease.  J Clin Oncol. 2001;19:4238-4244
PubMed
Rovensky J, Micekova D, Gubzova Z.  et al.  Treatment of knee osteoarthritis with a topical non-steroidal antiinflammatory drug: results of a randomized, double-blind, placebo-controlled study on the efficacy and safety of a 5% ibuprofen cream.  Drugs Exp Clin Res. 2001;27:209-221
PubMed
Noda K, Nishiwaki Y, Kawahara M.  et al.  Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer.  N Engl J Med. 2002;346:85-91
PubMed   |  Link to Article
Moss AJ, Zareba W, Hall WJ.  et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.  N Engl J Med. 2002;346:877-883
PubMed   |  Link to Article
Tsuyuki RT, Johnson JA, Teo KK.  et al.  A randomized trial of the effect of community pharmacist intervention on cholesterol risk management: the Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP).  Arch Intern Med. 2002;162:1149-1155
PubMed   |  Link to Article
Bernard P, Chosidow O, Vaillant L. Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial.  BMJ. 2002;325:864
PubMed   |  Link to Article
Gibson RL, Emerson J, McNamara S.  et al.  Significant microbiologic effect of inhaled tobramycin in young children with cystic fibrosis.  Am J Respir Crit Care Med. 2003;167:841-849
PubMed   |  Link to Article
Heemann U, Treichel U, Loock J.  et al.  Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study.  Hepatology. 2002;36:949-958
PubMed
Knowler WC, Barrett-Connor E, Fowler SE.  et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.  N Engl J Med. 2002;346:393-403
PubMed   |  Link to Article
Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W.Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators.  Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism.  N Engl J Med. 2002;347:1143-1150
PubMed   |  Link to Article
Lai KC, Lam SK, Chu KM.  et al.  Lansoprazole for the Prevention of Recurrences of Ulcer Complications from Long-Term Low-Dose Aspirin Use.  N Engl J Med. 2002;346:2033-2038
PubMed   |  Link to Article
Molyneux A. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial.  Lancet. 2002;360:1267-1274
PubMed   |  Link to Article
Moon JC, Kalra PR, Coats AJS. DANAMI-2: is primary angioplasty superior to thrombolysis in acute MI when the patient has to be transferred to an invasive centre?  Int J Cardiol. 2002;85:199-201
PubMed   |  Link to Article
Prandoni P, Bruchi O, Sabbion P.  et al.  Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study.  Arch Intern Med. 2002;162:1966-1971
PubMed   |  Link to Article
Weaver LK, Hopkins RO, Chan KJ.  et al.  Hyperbaric oxygen for acute carbon monoxide poisoning.  N Engl J Med. 2002;347:1057-1067
PubMed   |  Link to Article
Colhoun HM, Betteridge DJ, Durrington PN.  et al. CARDS Investigators.  Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.  Lancet. 2004;364:685-696
PubMed   |  Link to Article
Molina JM, Tourneur M, Sarfati C.  et al. Agence Nationale de Recherches sur le 090 Study Group.  Fumagillin treatment of intestinal microsporidiosis.  N Engl J Med. 2002;346:1963-1969
PubMed   |  Link to Article
Jones KL, Arslanian S, Peterokova VA, Park JS, Thomlinson MJ. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial.  Diabetes Care. 2002;25:89-94
PubMed   |  Link to Article
Chen-Mok M, Bangdiwala SI, Dominik R, Hays M, Irsula B, Sokal DC. Termination of a randomized controlled trial of two vasectomy techniques.  Control Clin Trials. 2003;24:78-84
PubMed   |  Link to Article
Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial.  Lancet. 2003;361:117-124
PubMed   |  Link to Article
Ferrer M, Esquinas A, Arancibia F.  et al.  Noninvasive ventilation during persistent weaning failure: a randomized controlled trial.  Am J Respir Crit Care Med. 2003;168:70-76
PubMed   |  Link to Article
Fudala PJ, Bridge TP, Herbert S.  et al. Buprenorphine/Naloxone Collaborative Study Group.  Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone.  N Engl J Med. 2003;349:949-958
PubMed   |  Link to Article
Goss PE, Ingle JN, Martino S.  et al.  A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.  N Engl J Med. 2003;349:1793-1802
PubMed   |  Link to Article
Higgins B, Thompson IM. The prostate cancer prevention trial: current status.  J Urol. 2004;171:S15-S17
PubMed   |  Link to Article
AFFIRM First Antiarrhythmic Drug Substudy Investigators.  Maintenance of sinus rhythm in patients with atrial fibrillation: an AFFIRM substudy of the first antiarrhythmic drug.  J Am Coll Cardiol. 2003;42:20-29
PubMed   |  Link to Article
Moore MJ, Hamm J, Dancey J.  et al. National Cancer Institute of Canada Clinical Trials Group.  Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.  J Clin Oncol. 2003;21:3296-3302
PubMed   |  Link to Article
Nademanee K, Veerakul G, Mower M.  et al.  Defibrillator versus beta-Blockers for Unexplained Death in Thailand (DEBUT): a randomized clinical trial.  Circulation. 2003;107:2221-2226
PubMed   |  Link to Article
Ortner ME, Caca K, Berr F.  et al.  Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study.  Gastroenterology. 2003;125:1355-1363
PubMed   |  Link to Article
Ridker PM, Goldhaber SZ, Danielson E.  et al. PREVENT Investigators.  Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism.  N Engl J Med. 2003;348:1425-1434
PubMed   |  Link to Article
Sandler RS, Halabi S, Baron JA.  et al.  A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer [published correction appears in N Engl J Med. 2003;348:1939].  N Engl J Med. 2003;348:883-890
PubMed   |  Link to Article
Schrader J, Luders S, Kulschewski A.  et al. Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group.  The ACCESS study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors.  Stroke. 2003;34:1699-1703
PubMed   |  Link to Article
Van Heek NT, De Castro SM, van Eijck CH.  et al.  The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer: a prospective randomized multicenter trial with special focus on assessment of quality of life.  Ann Surg. 2003;238:894-902
PubMed   |  Link to Article
Yang JC, Haworth L, Sherry RM.  et al.  A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.  N Engl J Med. 2003;349:427-434
PubMed   |  Link to Article
Cook TM, Porter MV. Randomized comparison of the classic Laryngeal Mask Airway with the Airway Management Device during anesthesia.  Br J Anaesth. 2003;91:672-677
PubMed   |  Link to Article
Mori K, Kondo T, Kamiyama Y, Kano Y, Tominaga K. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer.  Cancer Chemother Pharmacol. 2003;51:403-406
PubMed
Sever PS, Dahlof B, Poulter NR.  et al. ASCOT Investigators.  Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower than average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomized controlled trial.  Lancet. 2003;361:1149-1158
PubMed   |  Link to Article
Jacobs S, Price Evans DA, Tariq M, Al Omar NF. Fluconazole improves survival in septic shock: a randomized double blind prospective study.  Crit Care Med. 2003;31:1938-1946
PubMed   |  Link to Article
Matsumori A.Assessment of Response to Candesartan in Heart Failure in Japan (ARCH-J) Study Investigators.  Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure.  Eur J Heart Fail. 2003;5:669-677
PubMed   |  Link to Article
Markman M, Liu PY, Wilczynski S.  et al. Southwest Oncology Group/Gynecologic Oncology Group.  Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial.  J Clin Oncol. 2003;21:2460-2465
PubMed   |  Link to Article
O’Brien SG, Guilhot F, Larson RA.  et al. IRIS Investigators.  Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.  N Engl J Med. 2003;348:994-1004
PubMed   |  Link to Article
Chang AK, Schoeman G, Hill M. A randomized clinical trial to assess the efficacy of the Epley maneuver in the treatment of acute benign positional vertigo.  Acad Emerg Med. 2004;11:918-924
PubMed   |  Link to Article
Liaw YF, Sung JJ, Chow WC.  et al. Cirrhosis Asian Lamivudine Multicentre Study Group.  Lamivudine for patients with chronic hepatitis B and advanced liver disease.  N Engl J Med. 2004;351:1521-1531
PubMed   |  Link to Article
Saag MS, Cahn P, Raffi F.  et al. FTC-301A Study Team.  Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: a randomized trial.  JAMA. 2004;292:180-189
PubMed   |  Link to Article
Senat MV, Deprest J, Boulvain M, Paupe A, Winer N, Ville Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome.  N Engl J Med. 2004;351:136-144
PubMed   |  Link to Article
Trnavsky K, Fischer M, Vogtle-Junkert U, Schreyger F. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.  J Rheumatol. 2004;31:565-572
PubMed
Tsui MH, Ngan Kee WD, Ng FF, Lau TK. A double blinded randomised placebo-controlled study of intramuscular pethidine for pain relief in the first stage of labour.  BJOG. 2004;111:648-655
PubMed   |  Link to Article
Chintu C, Bhat GJ, Walker AS.  et al. CHAP Trial Team.  Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial.  Lancet. 2004;364:1865-1871
PubMed   |  Link to Article
Lallemant M, Jourdain G, Le Coeur S.  et al. Perinatal HIV Prevention Trial (Thailand) Investigators.  Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand.  N Engl J Med. 2004;351:217-228
PubMed   |  Link to Article
Suwelack B, Gerhardt U, Hohage H. Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy.  Am J Transplant. 2004;4:655-662
PubMed   |  Link to Article
Merten GJ, Burgess WP, Gray LV.  et al.  Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.  JAMA. 2004;291:2328-2334
PubMed   |  Link to Article
Taylor AL, Ziesche S, Yancy C.  et al. African-American Heart Failure Trial Investigators.  Combination of isosorbide dinitrate and hydralazine in blacks with heart failure [published correction appears in N Engl J Med. 2005;352:1276].  N Engl J Med. 2004;351:2049-2057
PubMed   |  Link to Article

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.