Author Contributions: Dr Douglas had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Douglas, Gruber.
Acquisition of data: Gruber, Meister, Watson, Krush, Lynch.
Analysis and interpretation of data: Douglas, Gruber, Bonner, Watson, Lynch.
Drafting of the manuscript: Douglas, Gruber, Bonner.
Critical revision of the manuscript for important intellectual content: Douglas, Gruber, Meister, Watson, Krush, Lynch.
Statistical analysis: Douglas, Gruber, Bonner, Watson, Lynch.
Obtained funding: Gruber.
Administrative, technical, or material support: Gruber, Meister, Bonner, Krush.
Study supervision: Gruber.
Financial Disclosures: None reported.
Funding/Support: This article was funded by revenue from the Nebraska cigarette taxes awarded to Creighton University by the Nebraska Department of Health and Human Services. Funding was also received from grants U01 CA86389 and R01 CA81488 from the National Institutes of Health, as well as from the Weinstein Foundation and Ravitz Foundation. Dr Lynch received salary support through the Charles F. and Mary C. Heider Endowed Chair in Cancer Research.
Role of the Sponsor: The National Cancer Institute, the Nebraska Department of Health and Human Services, the Weinstein Foundation, and the Ravitz Foundation had no direct involvement in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Disclaimer: The article’s contents are solely the responsibility of the authors and do not necessarily represent the official views of the State of Nebraska or the Department of Health and Human Services.
Acknowledgment: We thank all of the members of family G who participated in this study, and we gratefully acknowledge the Cancer Genetics Registries at Creighton University and the University of Michigan for providing data essential to this analysis. We also thank Richard Monson, Professor of Epidemiology at the Harvard University School of Public Health, for providing electronic data from the Connecticut Tumor Registry.