To the Editor: The relative risk reduction in the occurrence of early menopause in premenopausal patients with breast cancer undergoing chemotherapy achieved by adding a gonadotropin-releasing hormone (GnRH) analogue was 72% in the PROMISE-GIM6 (Prevention of Menopause Induced by Chemotherapy: a Study in Early Breast Cancer Patients—Gruppo Italiano Mammella 6) trial, but the absolute difference was 17%.1 Larger patient cohorts, including patients independent of hormone receptor status and aged between 40 and 45 years who might not derive any benefit from GnRH analogues, will be needed to demonstrate statistically significant but smaller clinical benefits.2
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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