Author Contributions: Drs Nanda and Olopade
had full access to all of the data in the study and take responsibility for
the integrity of the data and the accuracy of the data analysis.
Study concept and design: Nanda, Olopade.
Acquisition of data: Cummings, Fackenthal,
Sveen, Cobleigh, Esserman.
Analysis and interpretation of data: Nanda,
Schumm, Ademuyiwa, Esserman, Lindor, Neuhausen, Olopade.
Drafting of the manuscript: Nanda, Schumm,
Fackenthal, Sveen, Olopade.
Critical revision of the manuscript for important
intellectual content: Nanda, Schumm, Cummings, Fackenthal, Sveen, Ademuyiwa,
Cobleigh, Esserman, Lindor, Neuhausen, Olopade.
Statistical analysis: Schumm.
Obtained funding: Olopade.
Administrative, technical, or material support:
Nanda, Cummings, Fackenthal, Sveen, Ademuyiwa, Esserman, Neuhausen.
Study supervision: Olopade.
Financial Disclosures: None reported.
Funding/Support: This study was supported by
National Cancer Institute grant R01 CA89085-01A1, the Falk Medical Research
Trust, the Breast Cancer Research Foundation, and the Entertainment Industry
Fund National Women’s Cancer Research Alliance. Dr Olopade is a Doris
Duke Distinguished Clinical Scientist; Dr Nanda is supported by a Postdoctoral
Award from the US Army Department of Defense, grant W81XWH-04-1-0545; and
Dr Neuhausen is supported by National Institutes of Health grant CA74415.
Role of the Sponsors: None of the funding organizations
had any role in the design and conduct of the study; the collection, analysis,
and interpretation of the data; or the preparation, review, or approval of
Acknowledgment: We thank the staff at each
site, all of the families who participated in the study, and Myriad Genetics
Laboratory Inc, Salt Lake City, Utah.