Author Contributions: Dr Pasche had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Pasche, de la Chapelle,
Acquisition of data: Knobloch, Bian, Liu, Phukan,
Rosman, Kaklamani, Baddi, Siddiqui, Frankel, Prior, Schuller, Agrawal, Lang,
Dolan, Vokes, Lane, Caldes, Di Cristofano, Hampel, Nilsson, von Heijne, Murty,
de la Chapelle, Weghorst.
Analysis and interpretation of data: Pasche,
Knobloch, Liu, Phukan, Rosman, Baddi, Lane, Huang, Nilsson, von Heijne, Fodde,
de la Chapelle, Weghorst.
Drafting of the manuscript: Pasche, Knobloch,
Baddi, Huang, de la Chapelle, Weghorst.
Critical revision of the manuscript for important
intellectual content: Pasche, Knobloch, Bian, Liu, Phukan, Rosman,
Kaklamani, Siddiqui, Frankel, Prior, Schuller, Agrawal, Lang, Dolan, Vokes,
Lane, Caldes, Di Cristofano, Hampel, Nilsson, von Heijne, Fodde, Murty, de
la Chapelle, Weghorst.
Statistical analysis: Knobloch, Huang.
Obtained funding: Pasche, de la Chapelle, Weghorst.
Administrative, technical, or material support:
Pasche, Knobloch, Bian, Liu, Phukan, Rosman, Frankel, Schuller, Agrawal, Lang,
Dolan, Vokes, Lane, Caldes, Di Cristofano, Hampel, de la Chapelle.
Study supervision: Pasche, Weghorst.
Financial Disclosures: None reported.
Funding/Support: This work was supported by
grants CA90386 and CA89018 (Dr Pasche), DE/CA 11921 (Drs Vokes and Dolan),
CA67941 (Dr de la Chapelle) and P30 CA16058 (Ohio State University) from the
National Cancer Institute; P01 DE12704 (Drs Liu, Schuller, and Weghorst) and
R01 DE011943 (Dr Weghorst) from the National Institute of Dental and Craniofacial
Research; the Illinois Chapter of the American Cancer Society (Dr Pasche);
the Walter S. Mander Foundation, Chicago, Ill (Dr Pasche); The V Foundation,
Cary, NC (Dr Weghorst), the Dutch Cancer Society (Dr Frankel); and the Netherlands
Organization for Scientific Research (NWO/Vidi). Dr Pasche is the recipient
of a career development award from the Avon Foundation. This study was initiated
by Drs Pasche and Weghorst.
Role of the Sponsor: None of the funding agencies
were involved in the design and conduct, data management and analysis, manuscript
preparation and review, or authorization for submission.
Disclaimer: Dr Pasche was not involved in the
editorial review process nor in the decision about publication of this article.
Acknowledgment: We thank Jenny Panescu, BS,
and Yange Zhang, PhD, for the analysis of microsatellite markers, Adekunle
A. Raji, BS, for providing tissue samples, and Rosalyn Williams for collecting
information on the patients’ prior treatment. The authors acknowledge
the service provided by the Research Cytogenetics Core Facility, Human Genetics
Program, Fox Chase Cancer Center, for performing the CGH analysis.