Author Contributions: Drs Lanfear, McLeod,
and Spertus had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Lanfear, Marsh, Cresci,
Acquisition of data: Lanfear, McLeod, Spertus.
Analysis and interpretation of data: Lanfear,
Jones, Marsh, Cresci, McLeod, Spertus.
Drafting of the manuscript: Lanfear, Marsh,
Critical revision of the manuscript for important
intellectual content: Lanfear, Jones, Marsh, Cresci, McLeod, Spertus.
Statistical analysis: Lanfear, Jones, Spertus.
Obtained funding: McLeod, Spertus.
Administrative, technical, or material support:
Lanfear, Marsh, McLeod, Spertus.
Study supervision: Marsh, McLeod, Spertus.
Financial Disclosures: None reported.
Funding/Support: This work was supported in
part by grant R01 HS11282-01 from the Agency for Healthcare Research and Quality,
grant U01 GM63340 from the NIH Pharmacogenetics research network, an HFSA
Research Fellowship Grant, and grant P50 HL077113 from the Specialized Centers
of Clinically Oriented Research (SCCOR) program of the National Heart, Lung,
and Blood Institute.
Role of the Sponsors: The funding sources had
no role in the design, analysis, or interpretation of the manuscript.
Acknowledgment: We thank Adam Garsa, BA, Department
of Medicine, Washington University School of Medicine, for genotyping assistance
vital to this work. The data have been submitted to www.PharmGKB.org; PS205292.